Genetic analysis of the RELN gene: Gender specific association with Alzheimer's disease

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Abstract

Association between genetic variants of the reelin (RELN) gene and the risk for developing Alzheimer's disease (AD) was examined in a sample of 432 patients and 308 controls. Single marker and haplotype analyses revealed that the strongly linked rs528528 and rs607755 polymorphisms are associated with AD risk in a gender specific manner. Among men, but not in women the rs528528 T/T and rs607755 A/A genotypes were significantly associated with the susceptibility to AD.

Original languageEnglish
Pages (from-to)716-718
Number of pages3
JournalPsychiatry research
Volume230
Issue number2
DOIs
Publication statusPublished - Dec 15 2015

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Keywords

  • Alzheimer's disease
  • Association study
  • Reelin (RELN)

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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