Experiments are described, made with a view to studying the origin and function of mast ceUs in the vicinity of induced (benzopyrene), homologous (Ehrlich) and heterologous (Yoshida) tumours. It was found that the organism responded with mast ceR reaction to disturbances of tissue correlation, and developed plasma cell reaction in states of tissue immunity. It is suggested that mast cells, which may have various origins, inhibit tumorous growth by neutralizing the polysaccharides, necessary for a development of tumours, in the course of their genesis, i.e. during the process in which other cell types are transf6rmed into mast cells. Various theories regarding the origin of mast cells and their tumour inhibiting function are discussed.
ASJC Scopus subject areas
- Cancer Research