Genes for psychosis and creativity: A promoter polymorphism of the neuregulin 1 gene is related to creativity in people with high intellectual achievement

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Why are genetic polymorphisms related to severe mental disorders retained in the gene pool of a population? A possible answer is that these genetic variations may have a positive impact on psychological functions. Here, I show that a biologically relevant polymorphism of the promoter region of the neuregulin 1 gene (SNP8NRG243177/rs6994992) is associated with creativity in people with high intellectual and academic performance. Intriguingly, the highest creative achievements and creative-thinking scores were found in people who carried the T/T genotype, which was previously shown to be related to psychosis risk and altered prefrontal activation. ©

Original languageEnglish
Pages (from-to)1070-1073
Number of pages4
JournalPsychological Science
Volume20
Issue number9
DOIs
Publication statusPublished - Sep 2009

Fingerprint

Neuregulin-1
Creativity
Psychotic Disorders
Gene Pool
Genetic Polymorphisms
Genetic Promoter Regions
Mental Disorders
Genes
Genotype
Psychology
Population

ASJC Scopus subject areas

  • Psychology(all)

Cite this

@article{9bb6ab4e7d174fbcabaace5d69b294c7,
title = "Genes for psychosis and creativity: A promoter polymorphism of the neuregulin 1 gene is related to creativity in people with high intellectual achievement",
abstract = "Why are genetic polymorphisms related to severe mental disorders retained in the gene pool of a population? A possible answer is that these genetic variations may have a positive impact on psychological functions. Here, I show that a biologically relevant polymorphism of the promoter region of the neuregulin 1 gene (SNP8NRG243177/rs6994992) is associated with creativity in people with high intellectual and academic performance. Intriguingly, the highest creative achievements and creative-thinking scores were found in people who carried the T/T genotype, which was previously shown to be related to psychosis risk and altered prefrontal activation. {\circledC}",
author = "S. K{\'e}ri",
year = "2009",
month = "9",
doi = "10.1111/j.1467-9280.2009.02398.x",
language = "English",
volume = "20",
pages = "1070--1073",
journal = "Psychological Science",
issn = "0956-7976",
publisher = "SAGE Publications Inc.",
number = "9",

}

TY - JOUR

T1 - Genes for psychosis and creativity

T2 - A promoter polymorphism of the neuregulin 1 gene is related to creativity in people with high intellectual achievement

AU - Kéri, S.

PY - 2009/9

Y1 - 2009/9

N2 - Why are genetic polymorphisms related to severe mental disorders retained in the gene pool of a population? A possible answer is that these genetic variations may have a positive impact on psychological functions. Here, I show that a biologically relevant polymorphism of the promoter region of the neuregulin 1 gene (SNP8NRG243177/rs6994992) is associated with creativity in people with high intellectual and academic performance. Intriguingly, the highest creative achievements and creative-thinking scores were found in people who carried the T/T genotype, which was previously shown to be related to psychosis risk and altered prefrontal activation. ©

AB - Why are genetic polymorphisms related to severe mental disorders retained in the gene pool of a population? A possible answer is that these genetic variations may have a positive impact on psychological functions. Here, I show that a biologically relevant polymorphism of the promoter region of the neuregulin 1 gene (SNP8NRG243177/rs6994992) is associated with creativity in people with high intellectual and academic performance. Intriguingly, the highest creative achievements and creative-thinking scores were found in people who carried the T/T genotype, which was previously shown to be related to psychosis risk and altered prefrontal activation. ©

UR - http://www.scopus.com/inward/record.url?scp=69549138560&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=69549138560&partnerID=8YFLogxK

U2 - 10.1111/j.1467-9280.2009.02398.x

DO - 10.1111/j.1467-9280.2009.02398.x

M3 - Article

C2 - 19594860

AN - SCOPUS:69549138560

VL - 20

SP - 1070

EP - 1073

JO - Psychological Science

JF - Psychological Science

SN - 0956-7976

IS - 9

ER -