Generation of physiological and pathological high frequency oscillations: The role of perisomatic inhibition in sharp-wave ripple and interictal spike generation

Attila I. Gulyás, Tamás T. Freund

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

Sharp-wave-ripple complexes (SWRs) and interictal-spikes are physiological and pathological forms of irregularly occurring transient high activity events in the hippocampal EEG. They share similar features and carry high-frequency oscillations with different spectral features. Recent results reveal similarities and differences in the generation of the two types of transients, and argue that parvalbumin containing basket cells (PVBCs) are crucial in synchronizing neuronal activity in both cases. SWRs are generated in the reciprocally connected network of inhibitory PVBCs, while in the pathological case, synchronous failure of perisomatic inhibition triggers massive pyramidal cell buxrst firing. While physiological ripple oscillation is primarily the result of phasic perisomatic inhibitory currents, pathological high-frequency ripples are population spikes of partially synchronous, massively bursting, uninhibited pyramidal cells.

Original languageEnglish
Pages (from-to)26-32
Number of pages7
JournalCurrent Opinion in Neurobiology
Volume31
DOIs
Publication statusPublished - Apr 2015

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ASJC Scopus subject areas

  • Neuroscience(all)

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