Generation of physiological and pathological high frequency oscillations

The role of perisomatic inhibition in sharp-wave ripple and interictal spike generation

Attila I. Gulyás, T. Freund

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Sharp-wave-ripple complexes (SWRs) and interictal-spikes are physiological and pathological forms of irregularly occurring transient high activity events in the hippocampal EEG. They share similar features and carry high-frequency oscillations with different spectral features. Recent results reveal similarities and differences in the generation of the two types of transients, and argue that parvalbumin containing basket cells (PVBCs) are crucial in synchronizing neuronal activity in both cases. SWRs are generated in the reciprocally connected network of inhibitory PVBCs, while in the pathological case, synchronous failure of perisomatic inhibition triggers massive pyramidal cell buxrst firing. While physiological ripple oscillation is primarily the result of phasic perisomatic inhibitory currents, pathological high-frequency ripples are population spikes of partially synchronous, massively bursting, uninhibited pyramidal cells.

Original languageEnglish
Pages (from-to)26-32
Number of pages7
JournalCurrent Opinion in Neurobiology
Volume31
DOIs
Publication statusPublished - 2015

Fingerprint

Parvalbumins
Pyramidal Cells
Electroencephalography
Population

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

@article{e3937cc2f629408f81a03b7c99d5f598,
title = "Generation of physiological and pathological high frequency oscillations: The role of perisomatic inhibition in sharp-wave ripple and interictal spike generation",
abstract = "Sharp-wave-ripple complexes (SWRs) and interictal-spikes are physiological and pathological forms of irregularly occurring transient high activity events in the hippocampal EEG. They share similar features and carry high-frequency oscillations with different spectral features. Recent results reveal similarities and differences in the generation of the two types of transients, and argue that parvalbumin containing basket cells (PVBCs) are crucial in synchronizing neuronal activity in both cases. SWRs are generated in the reciprocally connected network of inhibitory PVBCs, while in the pathological case, synchronous failure of perisomatic inhibition triggers massive pyramidal cell buxrst firing. While physiological ripple oscillation is primarily the result of phasic perisomatic inhibitory currents, pathological high-frequency ripples are population spikes of partially synchronous, massively bursting, uninhibited pyramidal cells.",
author = "Guly{\'a}s, {Attila I.} and T. Freund",
year = "2015",
doi = "10.1016/j.conb.2014.07.020",
language = "English",
volume = "31",
pages = "26--32",
journal = "Current Opinion in Neurobiology",
issn = "0959-4388",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Generation of physiological and pathological high frequency oscillations

T2 - The role of perisomatic inhibition in sharp-wave ripple and interictal spike generation

AU - Gulyás, Attila I.

AU - Freund, T.

PY - 2015

Y1 - 2015

N2 - Sharp-wave-ripple complexes (SWRs) and interictal-spikes are physiological and pathological forms of irregularly occurring transient high activity events in the hippocampal EEG. They share similar features and carry high-frequency oscillations with different spectral features. Recent results reveal similarities and differences in the generation of the two types of transients, and argue that parvalbumin containing basket cells (PVBCs) are crucial in synchronizing neuronal activity in both cases. SWRs are generated in the reciprocally connected network of inhibitory PVBCs, while in the pathological case, synchronous failure of perisomatic inhibition triggers massive pyramidal cell buxrst firing. While physiological ripple oscillation is primarily the result of phasic perisomatic inhibitory currents, pathological high-frequency ripples are population spikes of partially synchronous, massively bursting, uninhibited pyramidal cells.

AB - Sharp-wave-ripple complexes (SWRs) and interictal-spikes are physiological and pathological forms of irregularly occurring transient high activity events in the hippocampal EEG. They share similar features and carry high-frequency oscillations with different spectral features. Recent results reveal similarities and differences in the generation of the two types of transients, and argue that parvalbumin containing basket cells (PVBCs) are crucial in synchronizing neuronal activity in both cases. SWRs are generated in the reciprocally connected network of inhibitory PVBCs, while in the pathological case, synchronous failure of perisomatic inhibition triggers massive pyramidal cell buxrst firing. While physiological ripple oscillation is primarily the result of phasic perisomatic inhibitory currents, pathological high-frequency ripples are population spikes of partially synchronous, massively bursting, uninhibited pyramidal cells.

UR - http://www.scopus.com/inward/record.url?scp=84906070958&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84906070958&partnerID=8YFLogxK

U2 - 10.1016/j.conb.2014.07.020

DO - 10.1016/j.conb.2014.07.020

M3 - Article

VL - 31

SP - 26

EP - 32

JO - Current Opinion in Neurobiology

JF - Current Opinion in Neurobiology

SN - 0959-4388

ER -