Generalized epilepsy evoked by freeze lesions in the mesencephalon of the cat

M. Molnár, J. E. Skinner

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2 Citations (Scopus)

Abstract

Epilepsy was induced by making freeze lesions bilaterally in the mesencephalic reticular formation of cats. The convulsive activity was equivalent to generalized status epilepticus, developing 15-20 min after the freeze lesions had been made. The animals died in this state 16-20 h after it had developed. The generalized seizure activity may have spread to rostral structures from the lesioned mesencephalic reticular formation generalizing instantenously, or have been triggered and maintained by a local irritative zone, surrounding the necrotized tissue caused by freezing. The cooling of the same cryoprobes, by which the freeze lesions had been made, had no effect on the status epilepticus, probably because only the necrotized tissue was cooled. The cooling of the inferior thalamic peduncles changed the pattern of epileptic discharges, indicating that thalamocortical structures played a role in sustaining it.

Original languageEnglish
Pages (from-to)299-310
Number of pages12
JournalActa Neurobiologiae Experimentalis
Volume43
Issue number6
Publication statusPublished - 1983

Fingerprint

Generalized Epilepsy
Status Epilepticus
Mesencephalon
Cats
Freezing
Epilepsy
Seizures
Midbrain Reticular Formation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Generalized epilepsy evoked by freeze lesions in the mesencephalon of the cat. / Molnár, M.; Skinner, J. E.

In: Acta Neurobiologiae Experimentalis, Vol. 43, No. 6, 1983, p. 299-310.

Research output: Contribution to journalArticle

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