Generalized changes in venous distensibility in postthrombotic patients

Andrea Ágnes Molnár, Astrid Apor, Vera Kristóf, G. Nádasy, I. Préda, Kálmán Hüttl, G. Acsády, E. Monos, V. Bérczi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Introduction: In situ biomechanical properties of peripheral large veins were compared between asymptomatic young patients who had previously unilateral femoro-popliteal deep venous thrombosis (DVT) and age-matched, healthy controls; the aim of this study was to assess local or generalized alterations of venous wall biomechanics in postthrombotic patients. Patients and methods: Inner diameters of both common femoral veins, right axillary vein, and right internal jugular veins were measured in two directions by ultrasonography. Venous pressure was altered by posture changes (standing and lying) and by application of graded and controlled Valsalva. Ten postthrombotic young patients without any symptoms and 11 age-matched control subjects were included. Results: In postthrombotic patients, both the affected and unaffected common femoral vein diameters and capacities were larger at low transmural pressures than those for the control group, but they demonstrated significantly less distensibility when higher pressures were applied. Similarly, in the internal jugular vein, capacity without Valsalva was significantly higher in postthrombotic patients and distensibility was reduced (statistically significant in the erect position). Pressure-induced changes in axillary vein diameter were negligible. Conclusions: In situ diameter and capacity changes, and in situ distensibility of the femoral veins on both sides (i.e., the side of previous thrombosis as well as the disease-free side) and of the jugular veins are reduced in the young DVT patients compared to veins of the age-matched, healthy controls. The pathophysiological mechanism of generalized venous wall changes in these young DVT patients remains unknown.

Original languageEnglish
Pages (from-to)639-645
Number of pages7
JournalThrombosis Research
Volume117
Issue number6
DOIs
Publication statusPublished - 2006

Fingerprint

Femoral Vein
Jugular Veins
Axillary Vein
Venous Thrombosis
Pressure
Veins
Venous Pressure
Posture
Biomechanical Phenomena
Ultrasonography
Thrombosis
Control Groups

Keywords

  • Axillary vein
  • Capacity
  • Common femoral vein
  • Distensibility
  • Internal jugular vein
  • Postthrombotic state
  • Valsalva
  • Veins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology

Cite this

Generalized changes in venous distensibility in postthrombotic patients. / Molnár, Andrea Ágnes; Apor, Astrid; Kristóf, Vera; Nádasy, G.; Préda, I.; Hüttl, Kálmán; Acsády, G.; Monos, E.; Bérczi, V.

In: Thrombosis Research, Vol. 117, No. 6, 2006, p. 639-645.

Research output: Contribution to journalArticle

Molnár, Andrea Ágnes ; Apor, Astrid ; Kristóf, Vera ; Nádasy, G. ; Préda, I. ; Hüttl, Kálmán ; Acsády, G. ; Monos, E. ; Bérczi, V. / Generalized changes in venous distensibility in postthrombotic patients. In: Thrombosis Research. 2006 ; Vol. 117, No. 6. pp. 639-645.
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AU - Molnár, Andrea Ágnes

AU - Apor, Astrid

AU - Kristóf, Vera

AU - Nádasy, G.

AU - Préda, I.

AU - Hüttl, Kálmán

AU - Acsády, G.

AU - Monos, E.

AU - Bérczi, V.

PY - 2006

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N2 - Introduction: In situ biomechanical properties of peripheral large veins were compared between asymptomatic young patients who had previously unilateral femoro-popliteal deep venous thrombosis (DVT) and age-matched, healthy controls; the aim of this study was to assess local or generalized alterations of venous wall biomechanics in postthrombotic patients. Patients and methods: Inner diameters of both common femoral veins, right axillary vein, and right internal jugular veins were measured in two directions by ultrasonography. Venous pressure was altered by posture changes (standing and lying) and by application of graded and controlled Valsalva. Ten postthrombotic young patients without any symptoms and 11 age-matched control subjects were included. Results: In postthrombotic patients, both the affected and unaffected common femoral vein diameters and capacities were larger at low transmural pressures than those for the control group, but they demonstrated significantly less distensibility when higher pressures were applied. Similarly, in the internal jugular vein, capacity without Valsalva was significantly higher in postthrombotic patients and distensibility was reduced (statistically significant in the erect position). Pressure-induced changes in axillary vein diameter were negligible. Conclusions: In situ diameter and capacity changes, and in situ distensibility of the femoral veins on both sides (i.e., the side of previous thrombosis as well as the disease-free side) and of the jugular veins are reduced in the young DVT patients compared to veins of the age-matched, healthy controls. The pathophysiological mechanism of generalized venous wall changes in these young DVT patients remains unknown.

AB - Introduction: In situ biomechanical properties of peripheral large veins were compared between asymptomatic young patients who had previously unilateral femoro-popliteal deep venous thrombosis (DVT) and age-matched, healthy controls; the aim of this study was to assess local or generalized alterations of venous wall biomechanics in postthrombotic patients. Patients and methods: Inner diameters of both common femoral veins, right axillary vein, and right internal jugular veins were measured in two directions by ultrasonography. Venous pressure was altered by posture changes (standing and lying) and by application of graded and controlled Valsalva. Ten postthrombotic young patients without any symptoms and 11 age-matched control subjects were included. Results: In postthrombotic patients, both the affected and unaffected common femoral vein diameters and capacities were larger at low transmural pressures than those for the control group, but they demonstrated significantly less distensibility when higher pressures were applied. Similarly, in the internal jugular vein, capacity without Valsalva was significantly higher in postthrombotic patients and distensibility was reduced (statistically significant in the erect position). Pressure-induced changes in axillary vein diameter were negligible. Conclusions: In situ diameter and capacity changes, and in situ distensibility of the femoral veins on both sides (i.e., the side of previous thrombosis as well as the disease-free side) and of the jugular veins are reduced in the young DVT patients compared to veins of the age-matched, healthy controls. The pathophysiological mechanism of generalized venous wall changes in these young DVT patients remains unknown.

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