A simple empirical formula enables the quantitative description of chiral autocatalysis. This formula was used for the prediction of the number of consecutive autocatalytic reaction cycles needed to obtain a high enantiomeric excess without chiral auxiliary or an asymmetric physical field (absolute enantioselective synthesis). The results show, that even less selective Soai-type systems can be used for absolute enantioselective synthesis, which, therefore, appears to be a fairly general phenomenon.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry