General toxicity and neurotoxicity of lead and mercury in combination with dimethoate in rats after subchronic oral exposure

Z. Lengyel, A. Lukács, A. Szabó, L. Nagymajtényi

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4 Citations (Scopus)

Abstract

Lead and mercury both have had numerous industrial, agricultural and household applications, resulting in wide-spread pollution with presence in food and drinking water. Dimethoate, a typical, frequently applied insecticide, is an organophosphate, hence neurotoxic. In the present study, 1/25 and 1/100 LD50 of lead (Pb acetate), mercury (HgCl2) and dimethoate were given, alone or in double combinations, to young adult male Wistar rats by gavage for 12 weeks. Body weight gain was followed by weekly measurements. After that, the rats were prepared for electrophysiology: in urethane anesthesia, the left hemisphere was exposed, and silver electrodes were placed on the primary somatosensory, visual and auditory area. Spontaneous and stimulus-evoked activity was recorded and analyzed for band spectrum, and for latency and duration. Finally, the animals were overdosed with urethane, dissected, and organ weights were measured. High-dose Pb and dimethoate caused a significant retardation in the body weight gain. The effect of other doses and combinations was lower. Spontaneous cortical activity was strongly changed towards higher frequencies by dimethoate, less strongly by Pb. The effect of low-dose Pb, when combined with low-dose Hg and dimethoate, was increased. On the cortical-evoked potentials, similar effects were seen. The results indicate that low-level environmental neurotoxicants may, in case of combined exposure, have unexpectedly strong effects.

Original languageEnglish
Pages (from-to)242-246
Number of pages5
JournalTrace Elements and Electrolytes
Volume23
Issue number4
Publication statusPublished - Dec 2006

Fingerprint

Dimethoate
Mercury
Toxicity
Rats
Urethane
Weight Gain
Body Weight
Electrophysiology
Mercuric Chloride
Auditory Cortex
Somatosensory Cortex
Organ Size
Organophosphates
Lethal Dose 50
Bioelectric potentials
Insecticides
Silver
Evoked Potentials
Drinking Water
Wistar Rats

Keywords

  • Dimethoate
  • Lead
  • Mercury
  • Neurotoxicity
  • Rat

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

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abstract = "Lead and mercury both have had numerous industrial, agricultural and household applications, resulting in wide-spread pollution with presence in food and drinking water. Dimethoate, a typical, frequently applied insecticide, is an organophosphate, hence neurotoxic. In the present study, 1/25 and 1/100 LD50 of lead (Pb acetate), mercury (HgCl2) and dimethoate were given, alone or in double combinations, to young adult male Wistar rats by gavage for 12 weeks. Body weight gain was followed by weekly measurements. After that, the rats were prepared for electrophysiology: in urethane anesthesia, the left hemisphere was exposed, and silver electrodes were placed on the primary somatosensory, visual and auditory area. Spontaneous and stimulus-evoked activity was recorded and analyzed for band spectrum, and for latency and duration. Finally, the animals were overdosed with urethane, dissected, and organ weights were measured. High-dose Pb and dimethoate caused a significant retardation in the body weight gain. The effect of other doses and combinations was lower. Spontaneous cortical activity was strongly changed towards higher frequencies by dimethoate, less strongly by Pb. The effect of low-dose Pb, when combined with low-dose Hg and dimethoate, was increased. On the cortical-evoked potentials, similar effects were seen. The results indicate that low-level environmental neurotoxicants may, in case of combined exposure, have unexpectedly strong effects.",
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T1 - General toxicity and neurotoxicity of lead and mercury in combination with dimethoate in rats after subchronic oral exposure

AU - Lengyel, Z.

AU - Lukács, A.

AU - Szabó, A.

AU - Nagymajtényi, L.

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N2 - Lead and mercury both have had numerous industrial, agricultural and household applications, resulting in wide-spread pollution with presence in food and drinking water. Dimethoate, a typical, frequently applied insecticide, is an organophosphate, hence neurotoxic. In the present study, 1/25 and 1/100 LD50 of lead (Pb acetate), mercury (HgCl2) and dimethoate were given, alone or in double combinations, to young adult male Wistar rats by gavage for 12 weeks. Body weight gain was followed by weekly measurements. After that, the rats were prepared for electrophysiology: in urethane anesthesia, the left hemisphere was exposed, and silver electrodes were placed on the primary somatosensory, visual and auditory area. Spontaneous and stimulus-evoked activity was recorded and analyzed for band spectrum, and for latency and duration. Finally, the animals were overdosed with urethane, dissected, and organ weights were measured. High-dose Pb and dimethoate caused a significant retardation in the body weight gain. The effect of other doses and combinations was lower. Spontaneous cortical activity was strongly changed towards higher frequencies by dimethoate, less strongly by Pb. The effect of low-dose Pb, when combined with low-dose Hg and dimethoate, was increased. On the cortical-evoked potentials, similar effects were seen. The results indicate that low-level environmental neurotoxicants may, in case of combined exposure, have unexpectedly strong effects.

AB - Lead and mercury both have had numerous industrial, agricultural and household applications, resulting in wide-spread pollution with presence in food and drinking water. Dimethoate, a typical, frequently applied insecticide, is an organophosphate, hence neurotoxic. In the present study, 1/25 and 1/100 LD50 of lead (Pb acetate), mercury (HgCl2) and dimethoate were given, alone or in double combinations, to young adult male Wistar rats by gavage for 12 weeks. Body weight gain was followed by weekly measurements. After that, the rats were prepared for electrophysiology: in urethane anesthesia, the left hemisphere was exposed, and silver electrodes were placed on the primary somatosensory, visual and auditory area. Spontaneous and stimulus-evoked activity was recorded and analyzed for band spectrum, and for latency and duration. Finally, the animals were overdosed with urethane, dissected, and organ weights were measured. High-dose Pb and dimethoate caused a significant retardation in the body weight gain. The effect of other doses and combinations was lower. Spontaneous cortical activity was strongly changed towards higher frequencies by dimethoate, less strongly by Pb. The effect of low-dose Pb, when combined with low-dose Hg and dimethoate, was increased. On the cortical-evoked potentials, similar effects were seen. The results indicate that low-level environmental neurotoxicants may, in case of combined exposure, have unexpectedly strong effects.

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