General functioning predicts reward and punishment learning in schizophrenia

Zsuzsanna Somlai, Ahmed A. Moustafa, S. Kéri, Catherine E. Myers, Mark A. Gluck

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Previous studies investigating feedback-driven reinforcement learning in patients with schizophrenia have provided mixed results. In this study, we explored the clinical predictors of reward and punishment learning using a probabilistic classification learning task. Patients with schizophrenia (n = 40) performed similarly to healthy controls (n = 30) on the classification learning task. However, more severe negative and general symptoms were associated with lower reward-learning performance, whereas poorer general psychosocial functioning was correlated with both lower reward- and punishment-learning performances. Multiple linear regression analyses indicated that general psychosocial functioning was the only significant predictor of reinforcement learning performance when education, antipsychotic dose, and positive, negative and general symptoms were included in the analysis. These results suggest a close relationship between reinforcement learning and general psychosocial functioning in schizophrenia.

Original languageEnglish
Pages (from-to)131-136
Number of pages6
JournalSchizophrenia Research
Volume127
Issue number1-3
DOIs
Publication statusPublished - Apr 2011

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Punishment
Reward
Schizophrenia
Learning
Antipsychotic Agents
Linear Models
Regression Analysis
Education

Keywords

  • General functioning
  • Positive and negative symptoms
  • Reinforcement learning
  • Reward
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

General functioning predicts reward and punishment learning in schizophrenia. / Somlai, Zsuzsanna; Moustafa, Ahmed A.; Kéri, S.; Myers, Catherine E.; Gluck, Mark A.

In: Schizophrenia Research, Vol. 127, No. 1-3, 04.2011, p. 131-136.

Research output: Contribution to journalArticle

Somlai, Zsuzsanna ; Moustafa, Ahmed A. ; Kéri, S. ; Myers, Catherine E. ; Gluck, Mark A. / General functioning predicts reward and punishment learning in schizophrenia. In: Schizophrenia Research. 2011 ; Vol. 127, No. 1-3. pp. 131-136.
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