General and electrophysiological toxic effects of manganese in rats following subacute administration in dissolved and nanoparticle form.

Edina Horváth, Zsuzsanna Máté, Szabolcs Takács, Péter Pusztai, András Sápi, Zoltán Kónya, László Nagymajtényi, András Papp

Research output: Contribution to journalArticle

Abstract

In an attempt to model occupational and environmental Mn exposures and their possible interaction, young male Wistar rats were exposed to Mn by oral administration in dissolved form (MnCl(2)·4H(2)O, 14.84 and 59.36 mg/kg b.w.) and by intratracheal application of MnO(2) nanoparticles (2.63 mg/kg b.w.). After 3 and 6 weeks oral, or 3 weeks oral plus 3 weeks intratracheal, exposure, general toxicological, and electrophysiological tests were done. Body weight gain was significantly reduced after 6 and 3 plus 3 weeks exposure, but the effect of the latter on the pace of weight gain was stronger. Organ weights signalized systemic stress and effect on lungs. Changes in evoked electrophysiological responses (cortical sensory evoked potential and nerve action potential) indicated that the 3 plus 3 weeks combined exposure caused equal or higher changes in the latency of these responses than 6 weeks of exposure, although the calculated summed Mn dose in the former case was lower. The results showed the importance of the physicochemical form of Mn in determining the toxic outcome, and suggested that neurofunctional markers of Mn action may indicate the human health effect better than conventional blood Mn measurement.

Original languageEnglish
Pages (from-to)520632
Number of pages1
JournalTheScientificWorldJournal [electronic resource]
Volume2012
Publication statusPublished - 2012
Externally publishedYes

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Poisons
Bioelectric potentials
Manganese
Nanoparticles
Weight Gain
Rats
manganese
Organ Size
Environmental Exposure
Evoked Potentials
Toxicology
Action Potentials
Reaction Time
Oral Administration
Wistar Rats
Blood
Body Weight
Health
Lung
blood

ASJC Scopus subject areas

  • Medicine(all)

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General and electrophysiological toxic effects of manganese in rats following subacute administration in dissolved and nanoparticle form. / Horváth, Edina; Máté, Zsuzsanna; Takács, Szabolcs; Pusztai, Péter; Sápi, András; Kónya, Zoltán; Nagymajtényi, László; Papp, András.

In: TheScientificWorldJournal [electronic resource], Vol. 2012, 2012, p. 520632.

Research output: Contribution to journalArticle

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AU - Pusztai, Péter

AU - Sápi, András

AU - Kónya, Zoltán

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