Pancreatic cancer is the fifth cause of cancer death in the developed world. It is a highly malignant disease, characterised by aggressive local spread and early locoregional and hepatic metastasis. Surgery offers the only prospect of long-term survival, but the resecability ratio is very low at the time of diagnosis. Conventional chemo- and radiotherapy are relatively ineffective, that is why development of newer therapeutic alternatives are encouraged. Gene therapy came into the lime-light of interest. Authors discuss the fundamental scientific principle and clinical experience in connection with gene therapy of pancreatic cancer. Different targets include antisense strategies, gene-replacement, gene-directed prodrug activation therapy, promoter gene strategies, as well as oncolytic viruses.
|Translated title of the contribution||Gene therapy in pancreatic cancer|
|Number of pages||5|
|Publication status||Published - Feb 1 2004|
ASJC Scopus subject areas