Gene expression profiles in peripheral blood for the diagnosis of autoimmune diseases

Bertalan Mesko, Szilard Poliska, Laszlo Nagy

Research output: Contribution to journalReview article

30 Citations (Scopus)

Abstract

Gene expression profiling in clinical genomics has yet to deliver robust and reliable approaches for developing diagnostics and contributing to personalized medicine. Owing to technological developments and the recent accumulation of expression profiles, it is a timely and relevant question whether peripheral blood gene expression profiling can be used routinely in clinical decision making. Here, we review the available gene expression profiling data of peripheral blood in autoimmune and chronic inflammatory diseases and suggest that peripheral blood mononuclear cells are suitable for descriptive and comparative gene expression analyses. A gene-disease interaction network in chronic inflammatory diseases, a general protocol for future studies and a decision tree for researchers are presented to facilitate standardization and adoption of this approach.

Original languageEnglish
Pages (from-to)223-233
Number of pages11
JournalTrends in Molecular Medicine
Volume17
Issue number4
DOIs
Publication statusPublished - Apr 1 2011

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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