Gene and cancer therapy--pseudorabies virus: a novel research and therapeutic tool?

Zsolt Boldogköi, Antal Nógrádi

Research output: Contribution to journalReview article

22 Citations (Scopus)

Abstract

The past decade has been marked by significant advances in the application of gene transfer into living cells of animals and humans, with the resulting catapulting of preclinical and basic scientific concepts into therapeutic trials. A variety of virus-mediated gene delivery techniques have proved to be superior to other methodologies. This article concisely reviews the current status of gene and tumor therapy, focusing on virus-based technologies, describes the molecular biology of neurotropic herpesviruses and the application of herpes simplex virus, a relative of pseudorabies virus (PRV) in gene transfer and cancer therapy protocols. Finally, it addresses the issue of whether PRV, a nonhuman pathogen, could serve as a suitable research and therapeutic tool as concerns genetic and tumor therapy.

Original languageEnglish
Pages (from-to)155-182
Number of pages28
JournalCurrent gene therapy
Volume3
Issue number2
DOIs
Publication statusPublished - Apr 2003

    Fingerprint

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Drug Discovery
  • Genetics(clinical)

Cite this