The activity of cyanide-sensitive, Cu-Zn superoxide dismutase (SOD) was studied in liver cytosols from H-2 congenic strains of mice. Higher SOD activity was found in livers of mice having H-2b/A.BY, B10, and C 3H.SW/ haplotypes than in those of H-2a, H-2k and H-2d haplotypes. Segregation studies supported these correlations. In H-2 recombinant strains of mice, the genes influencing the liver SOD activity occur, as ascertained by mapping techniques, at or near the H-2D region of the major histocompatibility complex.
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