Gene affecting superoxide dismutase activity linked to the histocompatibility complex in H-2 congenic mice

R. Novak, Z. Bosze, B. Matkovics, J. Fachet

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Abstract

The activity of cyanide-sensitive, Cu-Zn superoxide dismutase (SOD) was studied in liver cytosols from H-2 congenic strains of mice. Higher SOD activity was found in livers of mice having H-2b/A.BY, B10, and C 3H.SW/ haplotypes than in those of H-2a, H-2k and H-2d haplotypes. Segregation studies supported these correlations. In H-2 recombinant strains of mice, the genes influencing the liver SOD activity occur, as ascertained by mapping techniques, at or near the H-2D region of the major histocompatibility complex.

Original languageEnglish
Pages (from-to)86-87
Number of pages2
JournalScience
Volume207
Issue number4426
DOIs
Publication statusPublished - Jan 1 1980

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