Gene activation pathways of nerve growth factor signaling

A minireview

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

PC12 rat pheochromocytoma cells provide an excellent model system to study the mechanism of nerve growth factor-induced neuronal differentiation. PC12 cells expressing a dominant inhibitory Ras protein are being used to elucidate the role of this key signal transduction protein in gene activation events accompanying morphological differentiation of these cells. The possible involvement of Ras-dependent protein phosphorylation cascades in NGF-induced gene expression are discussed in this paper.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalNeurobiology
Volume4
Issue number1-2
Publication statusPublished - 1996

Fingerprint

ras Proteins
Nerve Growth Factor
Transcriptional Activation
PC12 Cells
Pheochromocytoma
Cell Differentiation
Signal Transduction
Phosphorylation
Gene Expression
Proteins

Keywords

  • Gene expression
  • Nerve growth factor (NGF)*
  • Neuronal differentiation
  • PC12 cells
  • Protein kinase cascades
  • Ras proteins

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Gene activation pathways of nerve growth factor signaling : A minireview. / Szeberényi, J.

In: Neurobiology, Vol. 4, No. 1-2, 1996, p. 1-11.

Research output: Contribution to journalArticle

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