Gender-specific association of vitamin D receptor polymorphism combinations with type 1 diabetes mellitus

B. Györffy, B. Vásárhelyi, Dóra Krikovszky, László Madácsy, A. Tordai, T. Tulassay, András Szabó

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Abstract

Objective: Recent data have indicated the significance of vitamin D receptor (VDR) polymorphisms in type 1 diabetes mellitus (T1DM). We have studied the association of five known restriction enzyme polymorphisms of the VDR gene in patients with T1DM. Design and Methods: One hundred and seven children with T1DM (T1DM for 5 years; age, 1-14 years; boys/girls, 57/50; body mass index, 17.0±2.3kg/m2; haemoglobin AIc (HbAIc), 7.87±1.05) and 103 healthy subjects were enrolled. The VDR polymorphisms ApaI, BsmI, FokI, TaqI and Tru9I ('a', 'b', 'f', 't' and 'u' alleles respectively) were investigated. Results: The 't' and 'T' alleles miss the Hardy-Weinberg equilibrium (P <0.01) in control and diabetic populations; we therefore excluded this polymorphism from further analysis. We did not find a difference in the allele prevalence in T1DM patients and controls of any of the five polymorphisms. However, when the 'b', 'a' and 'u' alleles were simultaneously compared in girls, there was a significantly higher prevalence in patients with diabetes compared with controls ('b' + 'a' + 'u' present/absent: healthy, 0/53; diabetic, 13/37; P <0.005). In boys Conclusions: The impact of the 't' allele cannot be investigated in this study population. Not a single VDR polymorphism increases the susceptibility to T1DM. The common presence of the 'b', 'a' and 'u' alleles greatly increases the probability of T1DM in girls.

Original languageEnglish
Pages (from-to)803-808
Number of pages6
JournalEuropean Journal of Endocrinology
Volume147
Issue number6
DOIs
Publication statusPublished - Dec 1 2002

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Calcitriol Receptors
Type 1 Diabetes Mellitus
Alleles
Population
Healthy Volunteers
Hemoglobins
Body Mass Index
Enzymes
Genes

ASJC Scopus subject areas

  • Endocrinology

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Gender-specific association of vitamin D receptor polymorphism combinations with type 1 diabetes mellitus. / Györffy, B.; Vásárhelyi, B.; Krikovszky, Dóra; Madácsy, László; Tordai, A.; Tulassay, T.; Szabó, András.

In: European Journal of Endocrinology, Vol. 147, No. 6, 01.12.2002, p. 803-808.

Research output: Contribution to journalArticle

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