Gender differences of blood rheological parameters in laboratory animals

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Although growing number of evidences supports the gender differences of hemorheological variables in human, little is known about this question in experimental animals. Investigating this question and giving laboratory-specific reference values, blood samples from healthy male and female CD rats and beagle dogs were tested for hematological parameters (microcell counter), blood and plasma viscosity (capillary viscometer), erythrocyte deformability (bulk filtrometry and ektacytometry), erythrocyte aggregation (light transmission aggregometer) and fibrinogen concentration (coagulometer). Besides the inter-species alterations we found hematological gender differences too regarding the red blood cell count and hematocrit. In rats the erythrocyte aggregation index was higher in females, while in beagle dogs the males showed significantly higher aggregation index values. In rats the red blood cell deformability showed better values in females. In beagle dogs this was the opposite, the males had better elongation index (EI) values in the function of shear stress (SS). Besides this it was also experienced that the shape of the canine EI - SS curves differed from the rats' values. Gender differences with inter-species alterations can be observed in laboratory animals (rats and dogs) that have to be taken under consideration during planning experiments and evaluating results.

Original languageEnglish
Pages (from-to)263-272
Number of pages10
JournalClinical Hemorheology and Microcirculation
Volume45
Issue number2-4
DOIs
Publication statusPublished - 2010

Fingerprint

Laboratory Animals
Dogs
Erythrocyte Aggregation
Erythrocyte Deformability
Blood Viscosity
Erythrocyte Count
Erythrocyte Indices
Hematocrit
Fibrinogen
Canidae
Reference Values
Erythrocytes
Light

Keywords

  • Blood viscosity
  • gender differences
  • laboratory animals
  • plasma viscosity
  • red blood cell aggregation
  • red blood cell deformability

ASJC Scopus subject areas

  • Hematology
  • Physiology
  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Gender differences of blood rheological parameters in laboratory animals. / Németh, N.; Kiss, Ferenc; Furka, I.; Mikó, I.

In: Clinical Hemorheology and Microcirculation, Vol. 45, No. 2-4, 2010, p. 263-272.

Research output: Contribution to journalArticle

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