A depresszió neurokognitív összetevo{double acute}inek és nemi különbségeinek vizsgálata

Translated title of the contribution: Gender differences in the neurocognitive components of depression

Sárosi Andrea, X. Gonda, Balogh Gabriella, A. Székely, M. Sasvári, G. Faludi

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The clinical symptoms of major depression are paralleled by typical neurocognitive deficits. Our aim was to investigate the gender differences in neurocognitive impairment in patients with major depressive disorder. Methods. 96 patients with acute major depressive disorder meeting DSM-IV criteria participated in our study. Depression was assessed by the Montgomery-Asberg Depression Rating Scale, the Hamilton Depression Scale and the Beck Depression Inventory. We measured neurocognitive functions associated with verbal learning and memory (Rey Auditive Verbal Learning Test), visual reconstruction and recall (Rey- Osterreith Complex Figure Test), selective attention, executive functions and inhibitory control (Trail Making Test, Stroop Test). Results. Depressive patients performed significantly worse than controls in all tests. We found no gender differences in any of the tests in the control group. Depressed women performed significantly worse on tests of cognitive interference threshold compared to depressed men (Stroop III). Depressed women performed significantly worse compared to depressed men in the test of visual recall (Rey-Osterreith Complex Figure Test). Conclusion. Depressed patients performed worse in all tests of neurocognitive function compared to healthy controls. Depressed women performed significantly worse compared to depressed men in tests of visuospatial recall and cognitive interference. In the light of neuroimaging studies our results suggest that in the background of gender differences we observed in depressed patients lateralisation of hippocampal function may play an important role.

Original languageHungarian
Pages (from-to)191-199
Number of pages9
JournalNeuropsychopharmacologia Hungarica
Volume10
Issue number4
Publication statusPublished - Oct 2008

Fingerprint

Depression
Verbal Learning
Major Depressive Disorder
Trail Making Test
Stroop Test
Executive Function
Neuroimaging
Diagnostic and Statistical Manual of Mental Disorders
Equipment and Supplies
Control Groups

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Neuropsychology and Physiological Psychology
  • Clinical Neurology

Cite this

A depresszió neurokognitív összetevo{double acute}inek és nemi különbségeinek vizsgálata. / Andrea, Sárosi; Gonda, X.; Gabriella, Balogh; Székely, A.; Sasvári, M.; Faludi, G.

In: Neuropsychopharmacologia Hungarica, Vol. 10, No. 4, 10.2008, p. 191-199.

Research output: Contribution to journalArticle

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