Gender difference in m-CPP challenge test in healthy volunteers

Mihály Arató, G. Bagdy

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Challenge test with oral m-CPP and placebo were performed in 12 healthy, young volunteers (6 male, 6 female) in a double-blind, placebo-controlled, cross-over study to assess possible gender differences in serotonergic responsivity. Women but not men showed significant prolactin and anxiety increase after administration of 0.25 mg/kg oral m-CPPP. Core temperature increased in both sexes compared to placebo. m-CPP induced significant physical symptoms only in men. Gender differences in serotonergic functions may have clinical significance with regard to differences in rates of some psychiatric disorders between the sexes.

Original languageEnglish
Pages (from-to)121-124
Number of pages4
JournalInternational Journal of Neuropsychopharmacology
Volume1
Issue number2
Publication statusPublished - Dec 1998

Fingerprint

Healthy Volunteers
Placebos
Physiological Sexual Dysfunctions
Prolactin
Cross-Over Studies
Psychiatry
Anxiety
Temperature
1-(3-chlorophenyl)piperazine
4-carboxy-5-(pyridyloxy-5'-phosphate)proline

Keywords

  • Anxiety
  • Gender
  • m-CPP
  • Prolactin
  • Serotonin

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Neuropsychology and Physiological Psychology

Cite this

Gender difference in m-CPP challenge test in healthy volunteers. / Arató, Mihály; Bagdy, G.

In: International Journal of Neuropsychopharmacology, Vol. 1, No. 2, 12.1998, p. 121-124.

Research output: Contribution to journalArticle

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