Gender-dependent dissociation between oxytocin but not ACTH, cortisol or TSH responses to m-chlorophenylpiperazine in healthy subjects

G. Bagdy, Mihaly Arato

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

m-chlorophenylpiperazine (m-CPP), a serotonin (5-HT) agonist with some selectivity for the 5-HT(2C) receptor subtype, which is widely used to examine 5-HT receptor function in human subjects, has been found to induce oxytocin and thyrotropin (TSH) responses in rodents. This study examined whether m-CPP had any effect on plasma oxytocin, TSH and aldosterone concentration in healthy volunteers using a double-blind, placebo-controlled crossover design. Plasma adrenocorticorticotropic hormone (ACTH) and cortisol responses, two generally accepted markers of m-CPP-induced 5-HT receptor activation, were measured in parallel. Male subjects (n = 7) received placebo, 0.25 and 0.5 mg/kg oral m-CPP. In female subjects (n = 5), the effects of placebo and 0.25 mg/kg m-CPP were studied. After placebo, given in the morning, ACTH, cortisol, TSH and aldosterone concentrations decreased over time. m-CPP 0.25 mg/kg avoided decreases in ACTH, cortisol and TSH concentrations; these responses were significant. At the dose of 0.5 mg/kg, m-CPP caused increase in ACTH, cortisol, TSH and aldosterone concentrations. Significant plasma oxytocin responses were found in female subjects only; thus this effect of m-CPP was statistically significantly gender dependent. Other responses to m-CPP were similar in male and female subjects. The present results suggest that there are clear differences, including dose and gender-dependent dissociations, among the 5-HT receptor agonist m-CPP- induced neuroendocrine responses.

Original languageEnglish
Pages (from-to)342-348
Number of pages7
JournalPsychopharmacology
Volume136
Issue number4
DOIs
Publication statusPublished - 1998

Fingerprint

Oxytocin
Hydrocortisone
Healthy Volunteers
Hormones
Serotonin Receptors
Aldosterone
Serotonin Receptor Agonists
Placebos
1-(3-chlorophenyl)piperazine
Receptor, Serotonin, 5-HT2C
Placebo Effect
Thyrotropin
Cross-Over Studies
Rodentia
Serotonin

Keywords

  • 5-HT(2C) receptor
  • Adrenocorticotropic hormone (ACTH)
  • Aldosterone
  • Cortisol
  • Human
  • Meta- chlorophenylpiperazine (m-CPP)
  • Oxytocin
  • Serotonin agonist
  • Thyrotropin (TSH)

ASJC Scopus subject areas

  • Pharmacology

Cite this

Gender-dependent dissociation between oxytocin but not ACTH, cortisol or TSH responses to m-chlorophenylpiperazine in healthy subjects. / Bagdy, G.; Arato, Mihaly.

In: Psychopharmacology, Vol. 136, No. 4, 1998, p. 342-348.

Research output: Contribution to journalArticle

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