Gels and liposomes in optimized ocular drug delivery: Studies on ciprofloxacin formulations

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Abstract

Ciprofloxacin (CPFX) containing therapeutic systems were developed using gel- and liposome-based formulations to minimize tear-driven dilution in the conjunctival sac, a long-pursued objective in ophthalmology. Physicochemical properties (pH, osmolarity, viscosity, expansivity, membrane fluidity and in vitro CPFX release rate) of the preparations were studied by the appropriate methods. For gel preparation, the bio-adhesive poly(vinyl alcohol) and polymethacrylic acid derivatives were applied in various concentrations. In our liposome-supported carrier systems, multilamellar vesicles from lecithin and α-l-dipalmithoyl-phosphatidylcholine provided the encapsulating agent. Electron paramagnetic resonance (EPR) spectroscopy was applied to study the molecular interactions in the ophthalmic formulations. The polymer hydrogels used in our preparations ensured a steady and prolonged active ingredient release. In addition, encapsulation of the CPFX into liposomes prolonged the in vitro release of the antibacterial agent depending on the lipid composition of the vesicles.

Original languageEnglish
Pages (from-to)34-40
Number of pages7
JournalInternational Journal of Pharmaceutics
Volume343
Issue number1-2
DOIs
Publication statusPublished - Oct 1 2007

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Keywords

  • Ciprofloxacin
  • Gel
  • Liposome
  • Ocular drug delivery system
  • Release

ASJC Scopus subject areas

  • Pharmaceutical Science

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