Gd3+ chelates of interest in magnetic resonance imaging (MRI): studies using 17O NMR and EPR at several magnetic fields

D. Hugh Powell, Gabriel González, Véronique Tissières, K. Micskei, E. Brücher, Lothar Helm, AndréE Merbach

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The combination of 17O NMR relaxation rate and chemical shift measurements and EPR linewidth measurements at several magnetic fields provides a powerful probe of water exchange, rotational dynamics and electronic relaxation in aqueous solutions of Gd3+ complexes. This information is important for the understanding of the proton relaxivity of the complexes. Variable pressure measurements show a change of water exchange mechanism from associatively activated on [Gd(H2O)8]3+ and [Gd(PDTA)(H2O)2]- to probably limiting dissociative on the MRI contrast agents [Gd(DTPA)(H2O)]2-, [Gd(DOTA)(H2O)] and [Gd(DTPA-BMA)(H2)O)]. This leads to relatively slow water exchange rates on the latter three complexes. For [Gd(DTPA-BMA)(H2O)], the exchange rate is sufficiently slow to have an effect on the inner sphere proton relaxivity, and hence on the interpretation of NMRD profiles.

Original languageEnglish
Pages (from-to)20-24
Number of pages5
JournalJournal of Alloys and Compounds
Volume207-208
Issue numberC
DOIs
Publication statusPublished - 1994

Fingerprint

gadodiamide
Magnetic resonance
Paramagnetic resonance
Nuclear magnetic resonance
Magnetic fields
Imaging techniques
Protons
Water
Gadolinium DTPA
Chemical shift
Pressure measurement
Linewidth
Contrast Media
Ion exchange

ASJC Scopus subject areas

  • Metals and Alloys

Cite this

Gd3+ chelates of interest in magnetic resonance imaging (MRI) : studies using 17O NMR and EPR at several magnetic fields. / Powell, D. Hugh; González, Gabriel; Tissières, Véronique; Micskei, K.; Brücher, E.; Helm, Lothar; Merbach, AndréE.

In: Journal of Alloys and Compounds, Vol. 207-208, No. C, 1994, p. 20-24.

Research output: Contribution to journalArticle

Powell, D. Hugh ; González, Gabriel ; Tissières, Véronique ; Micskei, K. ; Brücher, E. ; Helm, Lothar ; Merbach, AndréE. / Gd3+ chelates of interest in magnetic resonance imaging (MRI) : studies using 17O NMR and EPR at several magnetic fields. In: Journal of Alloys and Compounds. 1994 ; Vol. 207-208, No. C. pp. 20-24.
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