Gd(ABE-DTTA), a novel contrast agent, at the MRI-effective dose shows absence of deleterious physiological effects in dogs

Balázs Ruzsics, Pál Surányi, Pál Kiss, Brigitta C. Brott, Ada Elgavish, Nada H. Saab-Ismail, Tamás Simor, Gabriel A. Elgavish

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9 Citations (Scopus)

Abstract

The physiological effects of a novel MRI contrast agent, Gd(ABE-DTTA), were investigated in dogs, monitoring parameters in blood samples. Each animal (n = 8 in the short-term, n = 4 in the long-term group) underwent isoflurane anesthesia followed by the generation of myocardial infarction and received a contrast agent at the MRI effective dose. Blood samples were collected 24 and 48 h, and 7, 14, 28, 35, 49 and 56 days after contrast agent administration. No significant changes exceeding the normal range were detected in any of the investigated parameters except in alanine aminotransferase (ALT). ALT enzyme activity increased in the short-term group 24 and 48 h after agent administration as expected from the effect of isoflurane anesthesia. Between days 7 and 56 no elevation in ALT was observed. In dogs no substantial short- or long-term effect was observed on the investigated, physiological parameters after Gd(ABE-DTTA) administration at the MRI effective dose.

Original languageEnglish
Pages (from-to)188-194
Number of pages7
JournalPharmacology
Volume77
Issue number4
DOIs
Publication statusPublished - Aug 1 2006

Keywords

  • Gadolinium-based contrast agent
  • Ischemic heart disease
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Pharmacology

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    Ruzsics, B., Surányi, P., Kiss, P., Brott, B. C., Elgavish, A., Saab-Ismail, N. H., Simor, T., & Elgavish, G. A. (2006). Gd(ABE-DTTA), a novel contrast agent, at the MRI-effective dose shows absence of deleterious physiological effects in dogs. Pharmacology, 77(4), 188-194. https://doi.org/10.1159/000094864