GCKR gene functional variants in type 2 diabetes and metabolic syndrome: Do the rare variants associate with increased carotid intima-media thickness?

Márton Mohás, Péter Kisfali, Luca Járomi, Anita Maász, Eszter Fehér, Veronika Csöngei, Noémi Polgár, Eniko Sáfrány, Judit Cseh, Katalin Sümegi, Katalin Hetyésy, István Wittmann, Béla Melegh

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: Recent studies revealed that glucokinase regulatory protein (GCKR) variants (rs780094 and rs1260326) are associated with serum triglycerides and plasma glucose levels. Here we analyzed primarily the association of these two variants with the lipid profile and plasma glucose levels in Hungarian subjects with type 2 diabetes mellitus and metabolic syndrome; and also correlated the genotypes with the carotid intima-media thickness records.Methods: A total of 321 type 2 diabetic patients, 455 metabolic syndrome patients, and 172 healthy controls were genotyped by PCR-RFLP.Results: Both GCKR variants were found to associate with serum triglycerides and with fasting plasma glucose. However, significant association with the development of type 2 diabetes mellitus and metabolic syndrome could not be observed. Analyzing the records of the patients, a positive association of prevalence the GCKR homozygous functional variants and carotid intima-media thickness was found in the metabolic syndrome patients.Conclusions: Our results support that rs780094 and rs1260326 functional variants of the GCKR gene are inversely associated with serum triglycerides and fasting plasma glucose levels, as it was already reported for diabetic and metabolic syndrome patients in some other populations. Besides this positive replication, as a novel feature, our preliminary findings also suggest a cardiovascular risk role of the GCKR minor allele carriage based on the carotid intima-media thickness association.

Original languageEnglish
Article number79
JournalCardiovascular diabetology
Volume9
DOIs
Publication statusPublished - Nov 29 2010

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

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