Gating of sensory input by spontaneous cortical activity

Artur Luczak, Peter Bartho, Kenneth D. Harris

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

The activity of neural populations is determined not only by sensory inputs but also by internally generated patterns. During quiet wakefulness, the brain produces spontaneous firing events that can spread over large areas of cortex and have been suggested to underlie processes such as memory recall and consolidation. Here we demonstrate a different role for spontaneous activity in sensory cortex: gating of sensory inputs.We show that population activity in rat auditory cortex is composed of transient 50-100mspackets of spiking activity that occur irregularly during silence and sustained tone stimuli, but reliably at tone onset. Population activity within these packets had broadly consistent spatiotemporal structure, but the rate and also precise relative timing of action potentials varied between stimuli. Packet frequency varied with cortical state, with desynchronized state activity consistent with superposition of multiple overlapping packets. We suggest that such packets reflect the sporadic opening of a "gate" that allows auditory cortex to broadcast a representation of external sounds to other brain regions.

Original languageEnglish
Pages (from-to)1684-1695
Number of pages12
JournalJournal of Neuroscience
Volume33
Issue number4
DOIs
Publication statusPublished - Jan 23 2013

ASJC Scopus subject areas

  • Neuroscience(all)

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