Gasztroretentív hatóanyag-leadó rendszerek jellemzése

Translated title of the contribution: Gastroretentive dosage forms

Dorottya Kiss, R. Zelkó

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Gastroretentive dosage forms are drug delivery systems which remain in the stomach for an extended period of time, and allow both spacial and time control of drug liberation. Their application can be advantageous in the case of drugs that are absorbed mainly from the upper part of the gastrointestinal tract or are unstable in the medium of distal intestinal regions. They can also be used beneficially in the local therapy of the stomach. Because of the complicated and by many factors influenced physiology of this organ, the design of such delivery systems is a task requiring due foresight and knowledge, Gastroretentive dosage forms can be floating, expandable, bioadhesive, modified shape and high density systems according to the physical property leading to prolongation of gastric residence time. Combinations of the listed categories can occur as well. Several spirited ideas and solutions have come up in the literature for the preparation of such delivery systems, but there is still need for development in the field of implementation and prediction of in vivo behaviour before these dosage forms can be elemental part of clinical practice.

Original languageHungarian
Pages (from-to)169-176
Number of pages8
JournalActa Pharmaceutica Hungarica
Volume75
Issue number3
Publication statusPublished - 2005

Fingerprint

Dosage Forms
Stomach
Upper Gastrointestinal Tract
Drug Delivery Systems
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Gasztroretentív hatóanyag-leadó rendszerek jellemzése. / Kiss, Dorottya; Zelkó, R.

In: Acta Pharmaceutica Hungarica, Vol. 75, No. 3, 2005, p. 169-176.

Research output: Contribution to journalArticle

@article{1310e0fba2f141c7ad5f66fab0d2867c,
title = "Gasztroretent{\'i}v hat{\'o}anyag-lead{\'o} rendszerek jellemz{\'e}se",
abstract = "Gastroretentive dosage forms are drug delivery systems which remain in the stomach for an extended period of time, and allow both spacial and time control of drug liberation. Their application can be advantageous in the case of drugs that are absorbed mainly from the upper part of the gastrointestinal tract or are unstable in the medium of distal intestinal regions. They can also be used beneficially in the local therapy of the stomach. Because of the complicated and by many factors influenced physiology of this organ, the design of such delivery systems is a task requiring due foresight and knowledge, Gastroretentive dosage forms can be floating, expandable, bioadhesive, modified shape and high density systems according to the physical property leading to prolongation of gastric residence time. Combinations of the listed categories can occur as well. Several spirited ideas and solutions have come up in the literature for the preparation of such delivery systems, but there is still need for development in the field of implementation and prediction of in vivo behaviour before these dosage forms can be elemental part of clinical practice.",
author = "Dorottya Kiss and R. Zelk{\'o}",
year = "2005",
language = "Hungarian",
volume = "75",
pages = "169--176",
journal = "Acta Pharmaceutica Hungarica",
issn = "0001-6659",
publisher = "Magyar Gyogyszereszeti Tarsasag",
number = "3",

}

TY - JOUR

T1 - Gasztroretentív hatóanyag-leadó rendszerek jellemzése

AU - Kiss, Dorottya

AU - Zelkó, R.

PY - 2005

Y1 - 2005

N2 - Gastroretentive dosage forms are drug delivery systems which remain in the stomach for an extended period of time, and allow both spacial and time control of drug liberation. Their application can be advantageous in the case of drugs that are absorbed mainly from the upper part of the gastrointestinal tract or are unstable in the medium of distal intestinal regions. They can also be used beneficially in the local therapy of the stomach. Because of the complicated and by many factors influenced physiology of this organ, the design of such delivery systems is a task requiring due foresight and knowledge, Gastroretentive dosage forms can be floating, expandable, bioadhesive, modified shape and high density systems according to the physical property leading to prolongation of gastric residence time. Combinations of the listed categories can occur as well. Several spirited ideas and solutions have come up in the literature for the preparation of such delivery systems, but there is still need for development in the field of implementation and prediction of in vivo behaviour before these dosage forms can be elemental part of clinical practice.

AB - Gastroretentive dosage forms are drug delivery systems which remain in the stomach for an extended period of time, and allow both spacial and time control of drug liberation. Their application can be advantageous in the case of drugs that are absorbed mainly from the upper part of the gastrointestinal tract or are unstable in the medium of distal intestinal regions. They can also be used beneficially in the local therapy of the stomach. Because of the complicated and by many factors influenced physiology of this organ, the design of such delivery systems is a task requiring due foresight and knowledge, Gastroretentive dosage forms can be floating, expandable, bioadhesive, modified shape and high density systems according to the physical property leading to prolongation of gastric residence time. Combinations of the listed categories can occur as well. Several spirited ideas and solutions have come up in the literature for the preparation of such delivery systems, but there is still need for development in the field of implementation and prediction of in vivo behaviour before these dosage forms can be elemental part of clinical practice.

UR - http://www.scopus.com/inward/record.url?scp=26244442253&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=26244442253&partnerID=8YFLogxK

M3 - Article

VL - 75

SP - 169

EP - 176

JO - Acta Pharmaceutica Hungarica

JF - Acta Pharmaceutica Hungarica

SN - 0001-6659

IS - 3

ER -