Gastroprotective action of glucocorticoids during the formation and the healing of indomethacin-induced gastric erosions in rats

Ludmila Filaretova, Tatiana Podvigina, Tatiana Bagaeva, G. Makara

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The aim of the present study consisted of the investigation of glucocorticoid role in the formation and the healing of indomethacin-induced (25 mg/kg, sc) gastric erosions in rats. The effect of deficiency of glucocorticoid production followed by corticosterone replacement on the formation and the healing of the gastric erosions was evaluated. Glucocorticoid production was decreased by adrenalectomy or by delayed inhibitory action after a single pharmacological dose of cortisol (300 mg/kg ip) injected 1 week before the onset of ulcerogenic stimulus. Indomethacin induced corticosterone rise and caused gastric erosions. The loss of indomethacin-induced plasma corticosterone rise potentiated the formation of indomethacin-induced erosions in both models. The area of gastric erosions in rats with glucocorticoid deficiency was considerably larger than that in control animals 4 h after indomethacin administration as well as during 48 h after the drug administration (period of erosion healing). Injecting corticosterone in rats with glucocorticoid deficiency significantly decreased the formation of indomethacin-induced gastric erosions and promoted their healing. Thus, the present data support the gastroprotective action of glucocorticoids in the formation and in the healing of indomethacin-induced mucosal injury.

Original languageEnglish
Pages (from-to)201-208
Number of pages8
JournalJournal of Physiology Paris
Volume95
Issue number1-6
DOIs
Publication statusPublished - 2001

Fingerprint

Indomethacin
Glucocorticoids
Stomach
Corticosterone
Adrenalectomy
Hydrocortisone
Pharmacology
Wounds and Injuries
Pharmaceutical Preparations

Keywords

  • Adrenalectomy
  • Gastric erosions
  • Glucocorticoids
  • Indomethacin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology (medical)

Cite this

Gastroprotective action of glucocorticoids during the formation and the healing of indomethacin-induced gastric erosions in rats. / Filaretova, Ludmila; Podvigina, Tatiana; Bagaeva, Tatiana; Makara, G.

In: Journal of Physiology Paris, Vol. 95, No. 1-6, 2001, p. 201-208.

Research output: Contribution to journalArticle

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