Gastroprotection induced by capsaicin in healthy human subjects

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Aim: To evaluate the gastro-protective effect of capsaicin against the ethanol- and indomethacin (IND)-induced gastric mucosal damage in healthy human subjects. Methods: The effects of small doses (1-8 μg/mL, 100 mL) of capsaicin on the gastric acid secretion basal acid output (BAO) and its electrolyte concentration, gastric transmucosal potential difference (GTPD), ethanol- (5 mL 300 mL/L i.g.) and IND- (3×25 mg/d) induced gastric mucosal damage were tested in a randomized, prospective study of 84 healthy human subjects. The possible role of desensitization of capsaicin-sensitive afferents was tested by repeated exposures and during a prolonged treatment. Results: Intragastric application of capsaicin decreased the BAO and enhanced "non-parietal" component, GTPD in a dose-dependent manner. The decrease of GTPD evoked by ethanol was inhibited by the capsaicin application, which was reproducible. Gastric microbleeding induced by IND was inhibited by co-administration with capsaicin, but was not influenced by two weeks pretreatment with a daily capsaicin dose of 3×4OO μg i.g. Conclusion: Capsaicin in low concentration range protects against gastric injuries induced by ethanol or IND, which is attributed to stimulation of the sensory nerve endings.

Original languageEnglish
Pages (from-to)5180-5184
Number of pages5
JournalWorld Journal of Gastroenterology
Volume11
Issue number33
Publication statusPublished - Sep 7 2005

Fingerprint

Capsaicin
Healthy Volunteers
Stomach
Indomethacin
Ethanol
Acids
Gastric Acid
Sensory Receptor Cells
Evoked Potentials
Electrolytes
Prospective Studies
Wounds and Injuries

Keywords

  • Capsaicin
  • Ethanol
  • Gastric microbleeding
  • Gastric transmucosal potential difference
  • Gastroprotection
  • Healthy human subjects
  • Indomethacin

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Gastroprotection induced by capsaicin in healthy human subjects. / Mózsik, G.; Szolcsányi, J.; Rácz, I.

In: World Journal of Gastroenterology, Vol. 11, No. 33, 07.09.2005, p. 5180-5184.

Research output: Contribution to journalArticle

@article{d21cffd0194540f28bc0808ec74ab1c9,
title = "Gastroprotection induced by capsaicin in healthy human subjects",
abstract = "Aim: To evaluate the gastro-protective effect of capsaicin against the ethanol- and indomethacin (IND)-induced gastric mucosal damage in healthy human subjects. Methods: The effects of small doses (1-8 μg/mL, 100 mL) of capsaicin on the gastric acid secretion basal acid output (BAO) and its electrolyte concentration, gastric transmucosal potential difference (GTPD), ethanol- (5 mL 300 mL/L i.g.) and IND- (3×25 mg/d) induced gastric mucosal damage were tested in a randomized, prospective study of 84 healthy human subjects. The possible role of desensitization of capsaicin-sensitive afferents was tested by repeated exposures and during a prolonged treatment. Results: Intragastric application of capsaicin decreased the BAO and enhanced {"}non-parietal{"} component, GTPD in a dose-dependent manner. The decrease of GTPD evoked by ethanol was inhibited by the capsaicin application, which was reproducible. Gastric microbleeding induced by IND was inhibited by co-administration with capsaicin, but was not influenced by two weeks pretreatment with a daily capsaicin dose of 3×4OO μg i.g. Conclusion: Capsaicin in low concentration range protects against gastric injuries induced by ethanol or IND, which is attributed to stimulation of the sensory nerve endings.",
keywords = "Capsaicin, Ethanol, Gastric microbleeding, Gastric transmucosal potential difference, Gastroprotection, Healthy human subjects, Indomethacin",
author = "G. M{\'o}zsik and J. Szolcs{\'a}nyi and I. R{\'a}cz",
year = "2005",
month = "9",
day = "7",
language = "English",
volume = "11",
pages = "5180--5184",
journal = "World Journal of Gastroenterology",
issn = "1007-9327",
publisher = "WJG Press",
number = "33",

}

TY - JOUR

T1 - Gastroprotection induced by capsaicin in healthy human subjects

AU - Mózsik, G.

AU - Szolcsányi, J.

AU - Rácz, I.

PY - 2005/9/7

Y1 - 2005/9/7

N2 - Aim: To evaluate the gastro-protective effect of capsaicin against the ethanol- and indomethacin (IND)-induced gastric mucosal damage in healthy human subjects. Methods: The effects of small doses (1-8 μg/mL, 100 mL) of capsaicin on the gastric acid secretion basal acid output (BAO) and its electrolyte concentration, gastric transmucosal potential difference (GTPD), ethanol- (5 mL 300 mL/L i.g.) and IND- (3×25 mg/d) induced gastric mucosal damage were tested in a randomized, prospective study of 84 healthy human subjects. The possible role of desensitization of capsaicin-sensitive afferents was tested by repeated exposures and during a prolonged treatment. Results: Intragastric application of capsaicin decreased the BAO and enhanced "non-parietal" component, GTPD in a dose-dependent manner. The decrease of GTPD evoked by ethanol was inhibited by the capsaicin application, which was reproducible. Gastric microbleeding induced by IND was inhibited by co-administration with capsaicin, but was not influenced by two weeks pretreatment with a daily capsaicin dose of 3×4OO μg i.g. Conclusion: Capsaicin in low concentration range protects against gastric injuries induced by ethanol or IND, which is attributed to stimulation of the sensory nerve endings.

AB - Aim: To evaluate the gastro-protective effect of capsaicin against the ethanol- and indomethacin (IND)-induced gastric mucosal damage in healthy human subjects. Methods: The effects of small doses (1-8 μg/mL, 100 mL) of capsaicin on the gastric acid secretion basal acid output (BAO) and its electrolyte concentration, gastric transmucosal potential difference (GTPD), ethanol- (5 mL 300 mL/L i.g.) and IND- (3×25 mg/d) induced gastric mucosal damage were tested in a randomized, prospective study of 84 healthy human subjects. The possible role of desensitization of capsaicin-sensitive afferents was tested by repeated exposures and during a prolonged treatment. Results: Intragastric application of capsaicin decreased the BAO and enhanced "non-parietal" component, GTPD in a dose-dependent manner. The decrease of GTPD evoked by ethanol was inhibited by the capsaicin application, which was reproducible. Gastric microbleeding induced by IND was inhibited by co-administration with capsaicin, but was not influenced by two weeks pretreatment with a daily capsaicin dose of 3×4OO μg i.g. Conclusion: Capsaicin in low concentration range protects against gastric injuries induced by ethanol or IND, which is attributed to stimulation of the sensory nerve endings.

KW - Capsaicin

KW - Ethanol

KW - Gastric microbleeding

KW - Gastric transmucosal potential difference

KW - Gastroprotection

KW - Healthy human subjects

KW - Indomethacin

UR - http://www.scopus.com/inward/record.url?scp=26244461233&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=26244461233&partnerID=8YFLogxK

M3 - Article

C2 - 16127749

AN - SCOPUS:26244461233

VL - 11

SP - 5180

EP - 5184

JO - World Journal of Gastroenterology

JF - World Journal of Gastroenterology

SN - 1007-9327

IS - 33

ER -