Gastroprotection induced by capsaicin in healthy human subjects

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Aim: To evaluate the gastro-protective effect of capsaicin against the ethanol- and indomethacin (IND)-induced gastric mucosal damage in healthy human subjects. Methods: The effects of small doses (1-8 μg/mL, 100 mL) of capsaicin on the gastric acid secretion basal acid output (BAO) and its electrolyte concentration, gastric transmucosal potential difference (GTPD), ethanol- (5 mL 300 mL/L i.g.) and IND- (3×25 mg/d) induced gastric mucosal damage were tested in a randomized, prospective study of 84 healthy human subjects. The possible role of desensitization of capsaicin-sensitive afferents was tested by repeated exposures and during a prolonged treatment. Results: Intragastric application of capsaicin decreased the BAO and enhanced "non-parietal" component, GTPD in a dose-dependent manner. The decrease of GTPD evoked by ethanol was inhibited by the capsaicin application, which was reproducible. Gastric microbleeding induced by IND was inhibited by co-administration with capsaicin, but was not influenced by two weeks pretreatment with a daily capsaicin dose of 3×4OO μg i.g. Conclusion: Capsaicin in low concentration range protects against gastric injuries induced by ethanol or IND, which is attributed to stimulation of the sensory nerve endings.

Original languageEnglish
Pages (from-to)5180-5184
Number of pages5
JournalWorld journal of gastroenterology
Issue number33
Publication statusPublished - Sep 7 2005


  • Capsaicin
  • Ethanol
  • Gastric microbleeding
  • Gastric transmucosal potential difference
  • Gastroprotection
  • Healthy human subjects
  • Indomethacin

ASJC Scopus subject areas

  • Gastroenterology

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