A gastroparesis és kezelésének lehetoségei

Translated title of the contribution: Gastroparesis and its treatment options

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Gastroparesis is a disorder of gastric emptying that occurs in the absence of mechanical obstruction. Its cardinal features include nausea, vomiting, bloating, early satiety and discomfort. Weight loss, dehydration, electrolyte disturbances and malnutrition may develop in severe cases. The majority of cases is idiopathic, long standing diabetes mellitus is responsible for about 25-30% of cases. Diabetic gastroparesis may render glucose control extremely difficult, its treatment represents a major challenge. Besides frequent, small meals and psychological support, several drug options are available, however, their efficacy is limited and only a few randomized studies have been performed to date. Prokinetic agents (erythromycin, domperidon, metoclopramid) and antiemetics (phenotiazines, serotonin antagonists, butyrophenons) are the most wide-spread medicaments. Among the novel, recently developed agents, 5-HT4 serotonin receptor agonists and dopamin D2 receptor antagonists are the most promising. Injection of botulinum toxin into the pyloric sphincter resulted in faster gastric emptying and symptom alleviation in some studies. Gastric electric stimulation appears to be one of the most effective options, both low and high-frequency stimulation may alleviate symptoms. Gastrostomy/ jejunostomy and other surgical interventions are considered as "last resort".

Original languageHungarian
Pages (from-to)393-398
Number of pages6
JournalOrvosi Hetilap
Volume149
Issue number9
DOIs
Publication statusPublished - Mar 2 2008

Fingerprint

Gastroparesis
Gastric Emptying
Serotonin 5-HT4 Receptor Agonists
Domperidone
Jejunostomy
Serotonin Antagonists
Gastrostomy
Antiemetics
Botulinum Toxins
Pylorus
Erythromycin
Dehydration
Malnutrition
Nausea
Electrolytes
Electric Stimulation
Vomiting
Meals
Weight Loss
Stomach

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A gastroparesis és kezelésének lehetoségei. / Igaz, P.; Tulassay, Z.

In: Orvosi Hetilap, Vol. 149, No. 9, 02.03.2008, p. 393-398.

Research output: Contribution to journalArticle

@article{25ea973334694fd1826f2379ea02b3f5,
title = "A gastroparesis {\'e}s kezel{\'e}s{\'e}nek lehetos{\'e}gei",
abstract = "Gastroparesis is a disorder of gastric emptying that occurs in the absence of mechanical obstruction. Its cardinal features include nausea, vomiting, bloating, early satiety and discomfort. Weight loss, dehydration, electrolyte disturbances and malnutrition may develop in severe cases. The majority of cases is idiopathic, long standing diabetes mellitus is responsible for about 25-30{\%} of cases. Diabetic gastroparesis may render glucose control extremely difficult, its treatment represents a major challenge. Besides frequent, small meals and psychological support, several drug options are available, however, their efficacy is limited and only a few randomized studies have been performed to date. Prokinetic agents (erythromycin, domperidon, metoclopramid) and antiemetics (phenotiazines, serotonin antagonists, butyrophenons) are the most wide-spread medicaments. Among the novel, recently developed agents, 5-HT4 serotonin receptor agonists and dopamin D2 receptor antagonists are the most promising. Injection of botulinum toxin into the pyloric sphincter resulted in faster gastric emptying and symptom alleviation in some studies. Gastric electric stimulation appears to be one of the most effective options, both low and high-frequency stimulation may alleviate symptoms. Gastrostomy/ jejunostomy and other surgical interventions are considered as {"}last resort{"}.",
keywords = "Diabetes mellitus, Electric stimulation, Gastroparesis, Prokinetic agent",
author = "P. Igaz and Z. Tulassay",
year = "2008",
month = "3",
day = "2",
doi = "10.1556/OH.2008.28293",
language = "Hungarian",
volume = "149",
pages = "393--398",
journal = "Orvosi Hetilap",
issn = "0030-6002",
publisher = "Akademiai Kiado",
number = "9",

}

TY - JOUR

T1 - A gastroparesis és kezelésének lehetoségei

AU - Igaz, P.

AU - Tulassay, Z.

PY - 2008/3/2

Y1 - 2008/3/2

N2 - Gastroparesis is a disorder of gastric emptying that occurs in the absence of mechanical obstruction. Its cardinal features include nausea, vomiting, bloating, early satiety and discomfort. Weight loss, dehydration, electrolyte disturbances and malnutrition may develop in severe cases. The majority of cases is idiopathic, long standing diabetes mellitus is responsible for about 25-30% of cases. Diabetic gastroparesis may render glucose control extremely difficult, its treatment represents a major challenge. Besides frequent, small meals and psychological support, several drug options are available, however, their efficacy is limited and only a few randomized studies have been performed to date. Prokinetic agents (erythromycin, domperidon, metoclopramid) and antiemetics (phenotiazines, serotonin antagonists, butyrophenons) are the most wide-spread medicaments. Among the novel, recently developed agents, 5-HT4 serotonin receptor agonists and dopamin D2 receptor antagonists are the most promising. Injection of botulinum toxin into the pyloric sphincter resulted in faster gastric emptying and symptom alleviation in some studies. Gastric electric stimulation appears to be one of the most effective options, both low and high-frequency stimulation may alleviate symptoms. Gastrostomy/ jejunostomy and other surgical interventions are considered as "last resort".

AB - Gastroparesis is a disorder of gastric emptying that occurs in the absence of mechanical obstruction. Its cardinal features include nausea, vomiting, bloating, early satiety and discomfort. Weight loss, dehydration, electrolyte disturbances and malnutrition may develop in severe cases. The majority of cases is idiopathic, long standing diabetes mellitus is responsible for about 25-30% of cases. Diabetic gastroparesis may render glucose control extremely difficult, its treatment represents a major challenge. Besides frequent, small meals and psychological support, several drug options are available, however, their efficacy is limited and only a few randomized studies have been performed to date. Prokinetic agents (erythromycin, domperidon, metoclopramid) and antiemetics (phenotiazines, serotonin antagonists, butyrophenons) are the most wide-spread medicaments. Among the novel, recently developed agents, 5-HT4 serotonin receptor agonists and dopamin D2 receptor antagonists are the most promising. Injection of botulinum toxin into the pyloric sphincter resulted in faster gastric emptying and symptom alleviation in some studies. Gastric electric stimulation appears to be one of the most effective options, both low and high-frequency stimulation may alleviate symptoms. Gastrostomy/ jejunostomy and other surgical interventions are considered as "last resort".

KW - Diabetes mellitus

KW - Electric stimulation

KW - Gastroparesis

KW - Prokinetic agent

UR - http://www.scopus.com/inward/record.url?scp=40849124126&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=40849124126&partnerID=8YFLogxK

U2 - 10.1556/OH.2008.28293

DO - 10.1556/OH.2008.28293

M3 - Article

C2 - 18292033

AN - SCOPUS:40849124126

VL - 149

SP - 393

EP - 398

JO - Orvosi Hetilap

JF - Orvosi Hetilap

SN - 0030-6002

IS - 9

ER -