Gastrointestinalis stromalis tumorok. Saját tapasztalatok 29 eset kapcsán

Translated title of the contribution: Gastrointestinal tumors. Own observations on the basis of 29 cases

Zoltán Sápi, Rita Beáta Kovács, Miklós Bodó

Research output: Contribution to journalArticle

Abstract

42 Gastrointestinal mesenchymal tumors are analyzed by the authors with characterization of immunohistochemistry and DNA study. Out of 42 tumors, 29 GIST 3 leiomyoma, 4 leiomyosarcoma, 3 benign schwannoma, 1 soliter fibrous tumor, 1 inflammatory myofibroblastic tumor and 1 benign haemangiopericytoma were found. All 29 GIST but two could be characterized by c-kit (CD-117) and CD-34 positivity independently weather they displayed focal neurogenic and/or myogenic immunomarkers. In GIST group, 10 cases were benign, 6 borderline and 13 malignant. All benign cases were euploid by DNA study, the malignant tumours were highly aneuploid. Concerning the borderline GIST group by morphology, the aneuploid DNA content may speak for malignant biological behavior, and the diploid DNA content in low grade malignant GIST by morphology may speak for better outcome in the malignant group. There is a discussion about the nomenclature of this morphologycal group, about the role of the c-kit gene and the necessity of the immunohistochemistry and DNA content determination.

Translated title of the contributionGastrointestinal tumors. Own observations on the basis of 29 cases
Original languageHungarian
Pages (from-to)916-922
Number of pages7
JournalOrvosi hetilap
Volume146
Issue number18 SUPPL.1
Publication statusPublished - Dec 1 2005

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Sápi, Z., Kovács, R. B., & Bodó, M. (2005). Gastrointestinalis stromalis tumorok. Saját tapasztalatok 29 eset kapcsán. Orvosi hetilap, 146(18 SUPPL.1), 916-922.