Gastrointestinal tract as a part of immune defence

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The paper is devoted to reviewing the function of gastrointestinal mucosal immune system. Gut-associated lymphoid tissue (GALT) provides the host with protective mechanisms against invasion by potential pathogens across the mucosal surface, and on the other hand, it plays a role in the development of induced tolerance against harmless products of digestion and the normal intestinal flora, all of which are potentially immunogenic. First the organization of GALT, its afferent and efferent limbs are described, then the normal B cell homeostasis and finally the induced oral tolerance are discussed. Knowledge of mechanisms of mucosal immune response is essential to complete understanding of the pathogenesis and treatment of inflammatory gastrointestinal diseases as well.

Original languageEnglish
Pages (from-to)291-304
Number of pages14
JournalActa Physiologica Hungarica
Volume87
Issue number4
Publication statusPublished - 2000

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Lymphoid Tissue
Gastrointestinal Tract
Mucosal Immunity
Gastrointestinal Diseases
Digestion
Immune System
Homeostasis
B-Lymphocytes
Extremities
Gastrointestinal Microbiome

Keywords

  • Gut-associated lymphoid tissue
  • Induced oral tolerance
  • Mucosal immunity
  • Secretory immunoglobulins

ASJC Scopus subject areas

  • Physiology

Cite this

Gastrointestinal tract as a part of immune defence. / Pár, A.

In: Acta Physiologica Hungarica, Vol. 87, No. 4, 2000, p. 291-304.

Research output: Contribution to journalArticle

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