A gastrointestinalis traktus cytomegalovirus-fertozéseszervtranszplantált betegeken

Translated title of the contribution: Gastrointestinal cytomegalovirus infections in organ transplant patients

Antal Péter, Gábor Telkes, Marina Varga, Jeno Járay

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Cytomegalovirus (CMV) is a major pathogen of immunocompressed organ transplant patients. 80-90% of all transplant patients are infected by the virus; however, the incidence of CMV disease is 30-40%. Gastrointestinal CMV disease occurs in 10% of all transplants involving any part of the gastrointestinal tract. Mucosal injury, ulcerations, erosions, hemorrhage, gastrointestinal dysmotility, rarely gastrointestinal masses, perforations are the most common pathological findings of the CMV disease. The method of specific diagnostics is endoscopy with mucosal biopsy. The biopsy samples must be investigated histopathologically for specific cytomegalic cells with intranuclear ("owl's eye") and intracytoplasmatic inclusions. Different microbiological, immunohistochemical and molecular biological assays can be performed to detect CMV in the mucosa. In case of gastrointestinal CMV disease, both gastroenterological and antiviral treatment are needed by ganciclovir i.v. and/or valganciclovir orally. The prevention of the disease should be achieved by general prophylaxis in high-risk patients (oral valganciclovir, in special cases hyperimmune globulin), and by preemptive therapy using microbiological surveillance in middle-risk patients.

Original languageHungarian
Pages (from-to)2463-2470
Number of pages8
JournalOrvosi hetilap
Volume149
Issue number52
DOIs
Publication statusPublished - Dec 28 2008

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ASJC Scopus subject areas

  • Medicine(all)

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