Gastric mucosal endogenous prostacyclin levels are different in Brattleboro rats compared with Wistar strain

Research output: Contribution to journalArticle

Abstract

Homozygous Brattleboro rats were investigated and compared to normal (physiological) Wistar strain rats regarding their gastric mucosal endogenous prostacyclin (PG-I2) level. It seems that the Brattleboro animals have a significantly lower level of this important protective material. Wistar rats having an artificial pituitary stalk lesion (which is the artificial equivalent of homozygous Brattleboro animals) showed no differences in endogenous mucosal prostacyclin level compared to normal Wistar rats. Therefore, we concluded that this hitherto unknown property of the homozygous Brattleboro rats is genetically determined.

Original languageEnglish
Pages (from-to)173-175
Number of pages3
JournalJournal of Physiology Paris
Volume95
Issue number1-6
DOIs
Publication statusPublished - 2001

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Brattleboro Rats
Epoprostenol
Wistar Rats
Stomach
Pituitary Gland

Keywords

  • Brattleboro rat
  • Gastric mucosal prostacyclin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology (medical)

Cite this

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title = "Gastric mucosal endogenous prostacyclin levels are different in Brattleboro rats compared with Wistar strain",
abstract = "Homozygous Brattleboro rats were investigated and compared to normal (physiological) Wistar strain rats regarding their gastric mucosal endogenous prostacyclin (PG-I2) level. It seems that the Brattleboro animals have a significantly lower level of this important protective material. Wistar rats having an artificial pituitary stalk lesion (which is the artificial equivalent of homozygous Brattleboro animals) showed no differences in endogenous mucosal prostacyclin level compared to normal Wistar rats. Therefore, we concluded that this hitherto unknown property of the homozygous Brattleboro rats is genetically determined.",
keywords = "Brattleboro rat, Gastric mucosal prostacyclin",
author = "Balint, {Gabor A.} and M. G{\'a}lfi and A. Juh{\'a}sz and F. L{\'a}szl{\'o} and A. Riman{\'o}czy",
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AU - Balint, Gabor A.

AU - Gálfi, M.

AU - Juhász, A.

AU - László, F.

AU - Rimanóczy, A.

PY - 2001

Y1 - 2001

N2 - Homozygous Brattleboro rats were investigated and compared to normal (physiological) Wistar strain rats regarding their gastric mucosal endogenous prostacyclin (PG-I2) level. It seems that the Brattleboro animals have a significantly lower level of this important protective material. Wistar rats having an artificial pituitary stalk lesion (which is the artificial equivalent of homozygous Brattleboro animals) showed no differences in endogenous mucosal prostacyclin level compared to normal Wistar rats. Therefore, we concluded that this hitherto unknown property of the homozygous Brattleboro rats is genetically determined.

AB - Homozygous Brattleboro rats were investigated and compared to normal (physiological) Wistar strain rats regarding their gastric mucosal endogenous prostacyclin (PG-I2) level. It seems that the Brattleboro animals have a significantly lower level of this important protective material. Wistar rats having an artificial pituitary stalk lesion (which is the artificial equivalent of homozygous Brattleboro animals) showed no differences in endogenous mucosal prostacyclin level compared to normal Wistar rats. Therefore, we concluded that this hitherto unknown property of the homozygous Brattleboro rats is genetically determined.

KW - Brattleboro rat

KW - Gastric mucosal prostacyclin

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