Gas-liquid chromatographic method for the determination of tolperisone in human plasma

pharmacokinetic and comparative bioavailability studies

P. Miskolczi, L. Vereczkey, R. Frenkl

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

A new capillary GLC method for the determination of tolperisone in human plasma was developed. Pharmacokinetic and comparative bioavailability studies were carried out after i.v. administration and after oral administration of two different preparations of tolperisone. After i.v. administration of the drug the elimination half-life was found to be 1.55 ± 0.7 h (mean ± S.D.), the apparent volume of distribution to be 5.1 ± 1.0 l/kg (mean ± S.D.) and total body clearance to be 140.8 ± 33.8 l/h (mean ± S.D.). The oral bioavailability was found to be 22.3 ± 6.3% for Mydeton tablets and 16.7 ± 8.9% for Mydocalm tablets. There was no significant difference between the bioavailability of two oral tablets.

Original languageEnglish
Pages (from-to)695-700
Number of pages6
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume5
Issue number7
DOIs
Publication statusPublished - 1987

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Tolperisone
Plasma (human)
Pharmacokinetics
Biological Availability
Gases
Tablets
Liquids
Oral Administration
Half-Life
Pharmaceutical Preparations

Keywords

  • bioavailability.
  • Capillary GLC analysis
  • pharmacokinetics
  • tolperisone

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmaceutical Science

Cite this

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title = "Gas-liquid chromatographic method for the determination of tolperisone in human plasma: pharmacokinetic and comparative bioavailability studies",
abstract = "A new capillary GLC method for the determination of tolperisone in human plasma was developed. Pharmacokinetic and comparative bioavailability studies were carried out after i.v. administration and after oral administration of two different preparations of tolperisone. After i.v. administration of the drug the elimination half-life was found to be 1.55 ± 0.7 h (mean ± S.D.), the apparent volume of distribution to be 5.1 ± 1.0 l/kg (mean ± S.D.) and total body clearance to be 140.8 ± 33.8 l/h (mean ± S.D.). The oral bioavailability was found to be 22.3 ± 6.3{\%} for Mydeton tablets and 16.7 ± 8.9{\%} for Mydocalm tablets. There was no significant difference between the bioavailability of two oral tablets.",
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T1 - Gas-liquid chromatographic method for the determination of tolperisone in human plasma

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AU - Miskolczi, P.

AU - Vereczkey, L.

AU - Frenkl, R.

PY - 1987

Y1 - 1987

N2 - A new capillary GLC method for the determination of tolperisone in human plasma was developed. Pharmacokinetic and comparative bioavailability studies were carried out after i.v. administration and after oral administration of two different preparations of tolperisone. After i.v. administration of the drug the elimination half-life was found to be 1.55 ± 0.7 h (mean ± S.D.), the apparent volume of distribution to be 5.1 ± 1.0 l/kg (mean ± S.D.) and total body clearance to be 140.8 ± 33.8 l/h (mean ± S.D.). The oral bioavailability was found to be 22.3 ± 6.3% for Mydeton tablets and 16.7 ± 8.9% for Mydocalm tablets. There was no significant difference between the bioavailability of two oral tablets.

AB - A new capillary GLC method for the determination of tolperisone in human plasma was developed. Pharmacokinetic and comparative bioavailability studies were carried out after i.v. administration and after oral administration of two different preparations of tolperisone. After i.v. administration of the drug the elimination half-life was found to be 1.55 ± 0.7 h (mean ± S.D.), the apparent volume of distribution to be 5.1 ± 1.0 l/kg (mean ± S.D.) and total body clearance to be 140.8 ± 33.8 l/h (mean ± S.D.). The oral bioavailability was found to be 22.3 ± 6.3% for Mydeton tablets and 16.7 ± 8.9% for Mydocalm tablets. There was no significant difference between the bioavailability of two oral tablets.

KW - bioavailability.

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KW - pharmacokinetics

KW - tolperisone

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