Gas chromatographic method for the determination of nomifensine in human plasma

L. Vereczkey, G. Bianchetti, V. Rovei, A. Frigerio

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

An analytical method based on solvent extraction, formation of a fluorinated derivative and quantitation by gas-liquid chromatography using an electron capture detector has been developed for the determination of nomifensine in biological fluids. The specificity (controlled by mass spectrometry) and the sensitivity appear to be satisfactory for drug level measurements in human body fluids. Its relative simplicity in fact permits its use in serial analysis.

Original languageEnglish
Pages (from-to)451-456
Number of pages6
JournalJournal of Chromatography A
Volume116
Issue number2
DOIs
Publication statusPublished - Jan 21 1976

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Nomifensine
Plasma (human)
Level measurement
Body fluids
Liquid chromatography
Body Fluids
Solvent extraction
Human Body
Gas chromatography
Gas Chromatography
Mass spectrometry
Mass Spectrometry
Gases
Electrons
Derivatives
Detectors
Fluids
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Analytical Chemistry
  • Clinical Biochemistry
  • Molecular Medicine

Cite this

Gas chromatographic method for the determination of nomifensine in human plasma. / Vereczkey, L.; Bianchetti, G.; Rovei, V.; Frigerio, A.

In: Journal of Chromatography A, Vol. 116, No. 2, 21.01.1976, p. 451-456.

Research output: Contribution to journalArticle

Vereczkey, L. ; Bianchetti, G. ; Rovei, V. ; Frigerio, A. / Gas chromatographic method for the determination of nomifensine in human plasma. In: Journal of Chromatography A. 1976 ; Vol. 116, No. 2. pp. 451-456.
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