Gas antisolvent approach for the precipitation of α-methoxyphenylacetic acid (r)-1-cyclohexylethylamine diateromeric salt

A. Zodge, M. Kõrösi, M. Tárkányi, J. Madarász, I. Miklós Szilágyi, T. Sohajda, E. Székelya

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

One of the major drawbacks of diastereomeric salt precipitation based enantioseparation is the time and solvent requirement of crystallization. In the gas antisolvent (GAS) approach, supercritical carbon dioxide is applied as an antisolvent, and the precipitation takes place in a couple of minutes. By setting the process parameters diastereomeric excess, yields, and selectivity can be controlled. Applicability of the process is demonstrated on the resolution of racemic 2-methoxyphenylacetic acid with enantiopure (R)-(-)-1-cyclohexylethylamine. Diastereomeric excess values over 55 % along with 80 % yields were achieved at optimal conditions in a single step.

Original languageEnglish
Pages (from-to)335-341
Number of pages7
JournalChemical and Biochemical Engineering Quarterly
Volume31
Issue number3
DOIs
Publication statusPublished - 2017

Keywords

  • A-methoxyphenylacetic acid
  • Capillary electrophoresis
  • Optical resolution
  • Supercritical CO

ASJC Scopus subject areas

  • Biochemistry
  • Chemistry(all)
  • Process Chemistry and Technology

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