Gangliosides in acute myeloid leukaemia (AML) and non-hodgkin's lymphoma (NHL)

N. Anh-Tuan, J. Pick, A. Mód, S. R. Hollán

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Abstract

Gangliosides of human acute myelomonocytic leukaemia (AMMoL), acute monocytic leukaemia (AMoL) and lymphoblastoid (pre-B) lymphoma cells were analysed by overpressured thin-layer chromatography (OPTLC) followed by scanning densitometry. AMMoL cells were found to contain four gangliosides, viz. GM3 (47.2%), GM1 (31.8%), GD1a (7.5%) and an unidentified compound migrating between GM1 and GD1a (13.5%). In AMoL cells, six components were identified (GM3:51.3%, GM1:13.4%, GD3: 7.8%, GD1a: 4.7%, GD1b: 6%, and an unidentified compound migrating between GM2 and GM1). The total gangliosides extracted from pre-B lymphoma cells of the hand-mirror variant were composed of 10 species (GM3: 50.8%, GM2: 11.2%, GM1: 7.8%, GD3: 2.3%, GD1a: 1.1%, GD1b: 2.2%, GT1: 1.6%, and three unidentified components with chromatographic mobilities between GM2 and GD1a). Additional studies must still be performed to clarify the question as to whether ganglioside GD3 represent a qualitative glycolipid marker for AMoL and pre-B lymphoblastic lymphoma.

Original languageEnglish
Pages (from-to)1003-1007
Number of pages5
JournalEuropean Journal of Cancer and Clinical Oncology
Volume22
Issue number8
DOIs
Publication statusPublished - Aug 1986

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ASJC Scopus subject areas

  • Oncology

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