Ganglioside composition in common acute lymphoblastic leukaemia.

J. Pick, N. Anh-Tuan, A. Mód, S. Hollán

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Abstract

Human leukaemic lymphocytes of the common acute lymphoblastic leukaemia (cALL) subtype were analysed for ganglioside composition by over pressured layer chromatography-densitometry. Two major ganglioside components, GM3 (58.0-77.8% of the total sialic acid content) and GM1 (20.7%-29.2%), and some minor compounds, GM2 (trace amounts to 9.6%) and unidentified gangliosides with chromatographic mobility between GM1 and GD1a (trace to 12.6%), were isolated from these cells. The relative amount of GM3 in cALL cells was found to be about double that in normal lymphocytes (65.7% vs. 37.7%), but lower than in chronic lymphocytic leukaemia (CLL) cells (65.7% vs. 81.5%). The cALL cells contained trace amounts of the ganglioside GD3, a compound present in CLL cells (5.6%) but absent in normal lymphocytes.

Original languageEnglish
Pages (from-to)33-39
Number of pages7
JournalHaematologia
Volume19
Issue number1
Publication statusPublished - Jan 1 1986

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ASJC Scopus subject areas

  • Hematology

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