Galanin 3 receptor-deficient mice show no alteration in the oxazolone-induced contact dermatitis phenotype

Bálint Botz, Susanne M. Brunner, Ágnes Kemény, E. Pintér, Jason J. McDougall, Barbara Kofler, Z. Helyes

Research output: Contribution to journalLetter

2 Citations (Scopus)

Abstract

Allergic contact dermatitis (ACD) is an inflammatory skin disease induced by allergen exposure and characterized by erythema, oedema and immune cell infiltration. The sensory peptide galanin (GAL) and its three receptors (GAL1–3) are involved in regulating inflammation. As GAL and its receptors are expressed in human and murine skin and GAL expression is increased in oxazolone-induced contact allergy, it could play a role in dermatitis. As GAL reduces neurogenic plasma extravasation in the mouse skin via GAL3 activation, the role of GAL3 in the oxazolone-induced dermatitis model was explored. Following topical challenge with oxazolone, GAL3 gene-deficient mice showed a trend towards reduced ear thickness. Plasma extravasation and neutrophil infiltration increased considerably upon oxazolone challenge in both GAL3 knockout animals and wild-type controls without any observable effect of the gene deletion. We conclude that a lack of GAL3 does not influence oxazolone-induced ACD.

Original languageEnglish
Pages (from-to)725-727
Number of pages3
JournalExperimental Dermatology
Volume25
Issue number9
DOIs
Publication statusPublished - Sep 1 2016

Fingerprint

Receptor, Galanin, Type 3
Dermatitis
Oxazolone
Contact Dermatitis
Galanin
Phenotype
Skin
Allergic Contact Dermatitis
Infiltration
Galanin Receptors
Genes
Allergies
Plasmas
Wild Animals
Neutrophil Infiltration
Gene Deletion
Erythema
Skin Diseases
Allergens
Ear

Keywords

  • ear oedema
  • inflammation
  • myeloperoxidase
  • neuropeptide
  • plasma leakage

ASJC Scopus subject areas

  • Biochemistry
  • Medicine(all)
  • Molecular Biology
  • Dermatology

Cite this

Galanin 3 receptor-deficient mice show no alteration in the oxazolone-induced contact dermatitis phenotype. / Botz, Bálint; Brunner, Susanne M.; Kemény, Ágnes; Pintér, E.; McDougall, Jason J.; Kofler, Barbara; Helyes, Z.

In: Experimental Dermatology, Vol. 25, No. 9, 01.09.2016, p. 725-727.

Research output: Contribution to journalLetter

Botz, Bálint ; Brunner, Susanne M. ; Kemény, Ágnes ; Pintér, E. ; McDougall, Jason J. ; Kofler, Barbara ; Helyes, Z. / Galanin 3 receptor-deficient mice show no alteration in the oxazolone-induced contact dermatitis phenotype. In: Experimental Dermatology. 2016 ; Vol. 25, No. 9. pp. 725-727.
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AU - Helyes, Z.

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