Galactosylation with β-Galactosidase from bovine testes employing modified acceptor substrates

Ulrike Gambert, Raul Gonzalez Lio, Erzsébet Farkas, Joachim Thiem, Vicente Verez Bencomo, András Lipták

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Abstract

In this study β1-3 linked analogues of the T-antigen determinant were synthesized in preparative scale by transgalactosylation using β-galactosidase from bovine testes to give synthetic antigens. Accepters with modifications of the sugar residue such as α-glycosylated spacers, as well as GlcNAc-αOR- and 2dGal-αOR-substrates opened further possibilities for galactosylation.

Original languageEnglish
Pages (from-to)1285-1291
Number of pages7
JournalBioorganic and Medicinal Chemistry
Volume5
Issue number7
DOIs
Publication statusPublished - Jul 1 1997

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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