Gadolinium(III)-loaded nanoparticulate zeolites as potential high-field MRI contrast agents: Relationship between structure and relaxivity

Éva Csajbók, I. Bányai, Luce Vander Elst, Robert N. Muller, Wuzong Zhou, Joop A. Peters

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The effects of dealumination, pore size, and calcination on the efficiency (as expressed in the relaxivity) of Gd3+-loaded zeolites for potential application as magnetic resonance imaging (MRI) contrast agents were studied. Partial dealumination of zeolites NaY or NaA by treatment with (NH 4)2SiF6 or diluted HCl resulted in materials that, upon loading with Gd3+, had a much higher relaxivity than the corresponding non-dealuminated materials. Analysis of the 1H NMR dispersion profiles of the various zeolites showed that this can be mainly ascribed to an increase of the amount of water inside the zeolite cavities as a result of the destruction of walls between cavities. However, the average residence time of water inside the Gd3+-loaded cavities did not change significantly, which suggests that the windows of the Gd 3+-loaded cavities are not affected by the dealumination. Upon calcination, the Gd3+ ions moved to the small sodalite cavities and became less accessible for water, resulting in a decrease in relaxivity. The important role of diffusion for the relaxivity was demonstrated by a comparison of the relaxivity of Gd3+loaded zeolite NaY and NaA samples. NaA had much lower relaxivities due to the smaller pore sizes. The transversal relaxivities of the Gd3+-doped zeolites are comparable in magnitude to the longitudinal ones at low magnetic fields (1 MRI contrast agents at low field, and as T 2 agents at higher fields.

Original languageEnglish
Pages (from-to)4799-4807
Number of pages9
JournalChemistry - A European Journal
Volume11
Issue number16
DOIs
Publication statusPublished - Aug 5 2005

Fingerprint

Zeolites
Gadolinium
Magnetic resonance
Contrast Media
Imaging techniques
Calcination
Pore size
Water
Nuclear magnetic resonance
Magnetic fields
Ions

Keywords

  • Contrast agents
  • Gadolinium
  • Lanthanides
  • Magnetic resonance imaging
  • Zeolites

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Gadolinium(III)-loaded nanoparticulate zeolites as potential high-field MRI contrast agents : Relationship between structure and relaxivity. / Csajbók, Éva; Bányai, I.; Elst, Luce Vander; Muller, Robert N.; Zhou, Wuzong; Peters, Joop A.

In: Chemistry - A European Journal, Vol. 11, No. 16, 05.08.2005, p. 4799-4807.

Research output: Contribution to journalArticle

Csajbók, Éva ; Bányai, I. ; Elst, Luce Vander ; Muller, Robert N. ; Zhou, Wuzong ; Peters, Joop A. / Gadolinium(III)-loaded nanoparticulate zeolites as potential high-field MRI contrast agents : Relationship between structure and relaxivity. In: Chemistry - A European Journal. 2005 ; Vol. 11, No. 16. pp. 4799-4807.
@article{41021c3036214dde97daf4b85109fd48,
title = "Gadolinium(III)-loaded nanoparticulate zeolites as potential high-field MRI contrast agents: Relationship between structure and relaxivity",
abstract = "The effects of dealumination, pore size, and calcination on the efficiency (as expressed in the relaxivity) of Gd3+-loaded zeolites for potential application as magnetic resonance imaging (MRI) contrast agents were studied. Partial dealumination of zeolites NaY or NaA by treatment with (NH 4)2SiF6 or diluted HCl resulted in materials that, upon loading with Gd3+, had a much higher relaxivity than the corresponding non-dealuminated materials. Analysis of the 1H NMR dispersion profiles of the various zeolites showed that this can be mainly ascribed to an increase of the amount of water inside the zeolite cavities as a result of the destruction of walls between cavities. However, the average residence time of water inside the Gd3+-loaded cavities did not change significantly, which suggests that the windows of the Gd 3+-loaded cavities are not affected by the dealumination. Upon calcination, the Gd3+ ions moved to the small sodalite cavities and became less accessible for water, resulting in a decrease in relaxivity. The important role of diffusion for the relaxivity was demonstrated by a comparison of the relaxivity of Gd3+loaded zeolite NaY and NaA samples. NaA had much lower relaxivities due to the smaller pore sizes. The transversal relaxivities of the Gd3+-doped zeolites are comparable in magnitude to the longitudinal ones at low magnetic fields (1 MRI contrast agents at low field, and as T 2 agents at higher fields.",
keywords = "Contrast agents, Gadolinium, Lanthanides, Magnetic resonance imaging, Zeolites",
author = "{\'E}va Csajb{\'o}k and I. B{\'a}nyai and Elst, {Luce Vander} and Muller, {Robert N.} and Wuzong Zhou and Peters, {Joop A.}",
year = "2005",
month = "8",
day = "5",
doi = "10.1002/chem.200500039",
language = "English",
volume = "11",
pages = "4799--4807",
journal = "Chemistry - A European Journal",
issn = "0947-6539",
publisher = "Wiley-VCH Verlag",
number = "16",

}

TY - JOUR

T1 - Gadolinium(III)-loaded nanoparticulate zeolites as potential high-field MRI contrast agents

T2 - Relationship between structure and relaxivity

AU - Csajbók, Éva

AU - Bányai, I.

AU - Elst, Luce Vander

AU - Muller, Robert N.

AU - Zhou, Wuzong

AU - Peters, Joop A.

PY - 2005/8/5

Y1 - 2005/8/5

N2 - The effects of dealumination, pore size, and calcination on the efficiency (as expressed in the relaxivity) of Gd3+-loaded zeolites for potential application as magnetic resonance imaging (MRI) contrast agents were studied. Partial dealumination of zeolites NaY or NaA by treatment with (NH 4)2SiF6 or diluted HCl resulted in materials that, upon loading with Gd3+, had a much higher relaxivity than the corresponding non-dealuminated materials. Analysis of the 1H NMR dispersion profiles of the various zeolites showed that this can be mainly ascribed to an increase of the amount of water inside the zeolite cavities as a result of the destruction of walls between cavities. However, the average residence time of water inside the Gd3+-loaded cavities did not change significantly, which suggests that the windows of the Gd 3+-loaded cavities are not affected by the dealumination. Upon calcination, the Gd3+ ions moved to the small sodalite cavities and became less accessible for water, resulting in a decrease in relaxivity. The important role of diffusion for the relaxivity was demonstrated by a comparison of the relaxivity of Gd3+loaded zeolite NaY and NaA samples. NaA had much lower relaxivities due to the smaller pore sizes. The transversal relaxivities of the Gd3+-doped zeolites are comparable in magnitude to the longitudinal ones at low magnetic fields (1 MRI contrast agents at low field, and as T 2 agents at higher fields.

AB - The effects of dealumination, pore size, and calcination on the efficiency (as expressed in the relaxivity) of Gd3+-loaded zeolites for potential application as magnetic resonance imaging (MRI) contrast agents were studied. Partial dealumination of zeolites NaY or NaA by treatment with (NH 4)2SiF6 or diluted HCl resulted in materials that, upon loading with Gd3+, had a much higher relaxivity than the corresponding non-dealuminated materials. Analysis of the 1H NMR dispersion profiles of the various zeolites showed that this can be mainly ascribed to an increase of the amount of water inside the zeolite cavities as a result of the destruction of walls between cavities. However, the average residence time of water inside the Gd3+-loaded cavities did not change significantly, which suggests that the windows of the Gd 3+-loaded cavities are not affected by the dealumination. Upon calcination, the Gd3+ ions moved to the small sodalite cavities and became less accessible for water, resulting in a decrease in relaxivity. The important role of diffusion for the relaxivity was demonstrated by a comparison of the relaxivity of Gd3+loaded zeolite NaY and NaA samples. NaA had much lower relaxivities due to the smaller pore sizes. The transversal relaxivities of the Gd3+-doped zeolites are comparable in magnitude to the longitudinal ones at low magnetic fields (1 MRI contrast agents at low field, and as T 2 agents at higher fields.

KW - Contrast agents

KW - Gadolinium

KW - Lanthanides

KW - Magnetic resonance imaging

KW - Zeolites

UR - http://www.scopus.com/inward/record.url?scp=23744492091&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23744492091&partnerID=8YFLogxK

U2 - 10.1002/chem.200500039

DO - 10.1002/chem.200500039

M3 - Article

C2 - 15929138

AN - SCOPUS:23744492091

VL - 11

SP - 4799

EP - 4807

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

SN - 0947-6539

IS - 16

ER -