GABA receptor binding in rat cerebral cortex and superior cervical ganglion in the absence of GABAergic synapses

V. J. Balcar, F. Joó, P. Kása, I. E. Dammasch, J. R. Wolff

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

High affinity binding of [3H]γ-aminobutyric acid (GABA) to membrane-containing homogenates prepared from rat cerebral cortex (neonatal or adult) or from adult rat superior cervical ganglion (SCG) was tested for sensitivity to baclofen, bicuculline and several other analogues of GABA. Since no major differences were found between the tissues free of GABAergic synapses (SCG and neonatal cortex) and GABAergic synapse-rich adult rat cortex, it is suggested that the presence of GABAergic synapses does not play a decisive role in the determination of pharmacological sensitivities of high-affinity GABA receptors.

Original languageEnglish
Pages (from-to)269-274
Number of pages6
JournalNeuroscience Letters
Volume66
Issue number3
DOIs
Publication statusPublished - May 23 1986

Fingerprint

Superior Cervical Ganglion
GABA Receptors
Cerebral Cortex
Synapses
gamma-Aminobutyric Acid
Aminobutyrates
Baclofen
Bicuculline
Pharmacology
Membranes

Keywords

  • baclofen
  • bicuculline
  • development
  • GABAergic synapse
  • rat
  • γ-aminobutyric acid (GABA) receptor

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

GABA receptor binding in rat cerebral cortex and superior cervical ganglion in the absence of GABAergic synapses. / Balcar, V. J.; Joó, F.; Kása, P.; Dammasch, I. E.; Wolff, J. R.

In: Neuroscience Letters, Vol. 66, No. 3, 23.05.1986, p. 269-274.

Research output: Contribution to journalArticle

Balcar, V. J. ; Joó, F. ; Kása, P. ; Dammasch, I. E. ; Wolff, J. R. / GABA receptor binding in rat cerebral cortex and superior cervical ganglion in the absence of GABAergic synapses. In: Neuroscience Letters. 1986 ; Vol. 66, No. 3. pp. 269-274.
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