G72/G30 (DAOA) and juvenile-onset mood disorders

Lissette Gomez, Karen Wigg, Yu Feng, Eniko Kiss, Krisztina Kapornai, Zsuzsa Tamás, László Mayer, Ildikó Baji, Gabriella Daróczi, István Benák, Viola Osváth Kothencné, Edit Dombovári, Emília Kaczvinszk, Márta Besnyo, Julia Gádoros, Nicole King, Judit Székely, Maria Kovacs, Ágnes Vetró, James L. KennedyCathy L. Barr

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12 Citations (Scopus)

Abstract

The chromosome 13q region has been linked to bipolar disorder in a number of genome scans as well as focused linkage studies. Previously we identified linkage to the 13q32 region in a genome scan of 146 affected sibling pair families from Hungary with juvenile-onset mood disorders. Within this region are the overlapping genes G72/G30, with G72 now officially named as D-amino-acid oxidase activator (DAOA). This locus has been associated with panic disorder, schizophrenia, and bipolar disorder. In this study, we tested for association to 11 markers in these genes and mood disorders in a sample of 646 nuclear families identified with a proband with onset of a mood disorder before 14.9 years of age. We identified evidence for association to three markers within the gene (rs2391191, rs3918341, rs1935062), two of which had been associated with bipolar disorder in previous studies. When corrected for the number of markers tested, the results were no longer significant, however the prior evidence for association of this gene in multiple studies points to this gene as a potential contributor to juvenile-onset mood disorders.

Original languageEnglish
Pages (from-to)1007-1012
Number of pages6
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume150
Issue number7
DOIs
Publication statusPublished - Oct 5 2009

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Keywords

  • Association
  • Bipolar disorder
  • Child
  • DAOA
  • Depression
  • G72/G30
  • Genetics
  • Mood disorders

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

Gomez, L., Wigg, K., Feng, Y., Kiss, E., Kapornai, K., Tamás, Z., Mayer, L., Baji, I., Daróczi, G., Benák, I., Kothencné, V. O., Dombovári, E., Kaczvinszk, E., Besnyo, M., Gádoros, J., King, N., Székely, J., Kovacs, M., Vetró, Á., ... Barr, C. L. (2009). G72/G30 (DAOA) and juvenile-onset mood disorders. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 150(7), 1007-1012. https://doi.org/10.1002/ajmg.b.30904