G-protein beta-3-subunit and eNOS gene polymorphism in transplant recipients with long-term renal graft function

Ondřej Viklický, Jaroslav A. Hubáček, Štefan Vítko, Uwe W. Heemann, B. Vásárhelyi, Mathias Kohnle, Vladimír Teplan, Jiří Lácha, Attila J. Szabó

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Despite new immunosuppressive drugs, only a minority of graft survive over 15 years. The aim of our study was to determine the influence of gene polymorphisms in the G-protein-β3 subunit (Gβ3) and endothelial nitric oxide synthase (eNOS) on the long-term outcome of kidney grafts. Methods: Using PCR, corresponding genotypes in Gβ3 (C825T) and eNOS (G894T) gene polymorphism were evaluated in patients with preserved graft function over 15 years and in a control group of transplant recipients. Results: There were no differences in allele and genotype distributions of both polymorphisms between groups. In Gβ3 polymorphism, the 825T allele carriers had a significantly lower body mass index while in eNOS polymorphism there were no links between genotypes, renal function and atherosclerosis risk factors. Conclusions: Our data suggest that these gene polymorphisms have only a minor influence on long-term renal graft function.

Original languageEnglish
Pages (from-to)245-249
Number of pages5
JournalKidney and Blood Pressure Research
Volume25
Issue number4
DOIs
Publication statusPublished - 2002

Fingerprint

Nitric Oxide Synthase Type III
Transplants
Kidney
Genotype
Genes
Alleles
Protein Subunits
Immunosuppressive Agents
GTP-Binding Proteins
Atherosclerosis
Body Mass Index
Polymerase Chain Reaction
Control Groups
G-protein beta3 subunit
Transplant Recipients
Pharmaceutical Preparations

Keywords

  • Endothelial nitric oxide synthase
  • G protein
  • Gene polymorphism
  • Kidney transplantation
  • Long-term graft survival

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Cardiology and Cardiovascular Medicine

Cite this

G-protein beta-3-subunit and eNOS gene polymorphism in transplant recipients with long-term renal graft function. / Viklický, Ondřej; Hubáček, Jaroslav A.; Vítko, Štefan; Heemann, Uwe W.; Vásárhelyi, B.; Kohnle, Mathias; Teplan, Vladimír; Lácha, Jiří; Szabó, Attila J.

In: Kidney and Blood Pressure Research, Vol. 25, No. 4, 2002, p. 245-249.

Research output: Contribution to journalArticle

Viklický, O, Hubáček, JA, Vítko, Š, Heemann, UW, Vásárhelyi, B, Kohnle, M, Teplan, V, Lácha, J & Szabó, AJ 2002, 'G-protein beta-3-subunit and eNOS gene polymorphism in transplant recipients with long-term renal graft function', Kidney and Blood Pressure Research, vol. 25, no. 4, pp. 245-249. https://doi.org/10.1159/000066346
Viklický, Ondřej ; Hubáček, Jaroslav A. ; Vítko, Štefan ; Heemann, Uwe W. ; Vásárhelyi, B. ; Kohnle, Mathias ; Teplan, Vladimír ; Lácha, Jiří ; Szabó, Attila J. / G-protein beta-3-subunit and eNOS gene polymorphism in transplant recipients with long-term renal graft function. In: Kidney and Blood Pressure Research. 2002 ; Vol. 25, No. 4. pp. 245-249.
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AU - Heemann, Uwe W.

AU - Vásárhelyi, B.

AU - Kohnle, Mathias

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AB - Background: Despite new immunosuppressive drugs, only a minority of graft survive over 15 years. The aim of our study was to determine the influence of gene polymorphisms in the G-protein-β3 subunit (Gβ3) and endothelial nitric oxide synthase (eNOS) on the long-term outcome of kidney grafts. Methods: Using PCR, corresponding genotypes in Gβ3 (C825T) and eNOS (G894T) gene polymorphism were evaluated in patients with preserved graft function over 15 years and in a control group of transplant recipients. Results: There were no differences in allele and genotype distributions of both polymorphisms between groups. In Gβ3 polymorphism, the 825T allele carriers had a significantly lower body mass index while in eNOS polymorphism there were no links between genotypes, renal function and atherosclerosis risk factors. Conclusions: Our data suggest that these gene polymorphisms have only a minor influence on long-term renal graft function.

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