G-protein beta-3-subunit and eNOS gene polymorphism in transplant recipients with long-term renal graft function

Ondřej Viklický, Jaroslav A. Hubáček, Štefan Vítko, Uwe W. Heemann, Barna Vasarhelyi, Mathias Kohnle, Vladimír Teplan, Jiří Lácha, Attila J. Szabó

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8 Citations (Scopus)

Abstract

Background: Despite new immunosuppressive drugs, only a minority of graft survive over 15 years. The aim of our study was to determine the influence of gene polymorphisms in the G-protein-β3 subunit (Gβ3) and endothelial nitric oxide synthase (eNOS) on the long-term outcome of kidney grafts. Methods: Using PCR, corresponding genotypes in Gβ3 (C825T) and eNOS (G894T) gene polymorphism were evaluated in patients with preserved graft function over 15 years and in a control group of transplant recipients. Results: There were no differences in allele and genotype distributions of both polymorphisms between groups. In Gβ3 polymorphism, the 825T allele carriers had a significantly lower body mass index while in eNOS polymorphism there were no links between genotypes, renal function and atherosclerosis risk factors. Conclusions: Our data suggest that these gene polymorphisms have only a minor influence on long-term renal graft function.

Original languageEnglish
Pages (from-to)245-249
Number of pages5
JournalKidney and Blood Pressure Research
Volume25
Issue number4
DOIs
Publication statusPublished - Dec 1 2002

Keywords

  • Endothelial nitric oxide synthase
  • G protein
  • Gene polymorphism
  • Kidney transplantation
  • Long-term graft survival

ASJC Scopus subject areas

  • Nephrology
  • Cardiology and Cardiovascular Medicine

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    Viklický, O., Hubáček, J. A., Vítko, Š., Heemann, U. W., Vasarhelyi, B., Kohnle, M., Teplan, V., Lácha, J., & Szabó, A. J. (2002). G-protein beta-3-subunit and eNOS gene polymorphism in transplant recipients with long-term renal graft function. Kidney and Blood Pressure Research, 25(4), 245-249. https://doi.org/10.1159/000066346