G and P types of circulating rotavirus strains in the United States during 1996-2005: Nine years of prevaccine data

Jon R. Gentsch, Jennifer J. Hull, Elizabeth N. Teel, Tara K. Kerin, Molly M. Freeman, Mathew D. Esona, Dixie D. Griffin, Brittany P. Bielfelt-Krall, Krisztian Banyai, Baoming Jiang, Margaret M. Cortese, Roger I. Glass, Umesh D. Parashar

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Abstract

Background. Rotavirus vaccine was recommended for routine use among US infants in 2006. To provide prevaccine data, we conducted strain surveillance for 9 consecutive seasons during 1996-2005. Methods. Using reverse-transcriptase polymerase chain reaction genotyping and nucleotide sequencing, we determined P/G genotypes of 13100 rotavirus strains collected in up to 12 cities each year from different US regions. Results. The most prevalent strain globally, P[8] G1, was the most prevalent each year in the United States (overall, 78.5% of strains; range, 60.0%-93.9%), and 9.2% of the samples were P[4] G2, 3.6% were P[8] G9, 1.7% were P[8] G3, and 0.8% were P[8] G4. Genotype P[6] G9, which emerged in 1995, was detected continuously for several seasons (from 1996-1997 to 2000-2001, 0.2%-5.4%) but was not identified in the subsequent 4 seasons. Single or a few detections of rare genotypes (eg, P[6] G12, P[9] G6, and P[9] G3) were observed during several rotavirus seasons at frequencies of 0.5%-1.7% and, overall, comprised 0.6% of all the samples from the entire surveillance period. Several globally common strains in addition to G1, especially G2 and G9, circulated at high prevalence (33%-62%) in some cities during certain years. Conclusions. Almost 85% of strains during 1996-2005 had either a G or P antigen that is present in both RotaTeq (Merck) and Rotarix (GlaxoSmithKline). Monitoring of strains after introduction of rotavirus vaccines is important.

Original languageEnglish
Pages (from-to)S99-S105
JournalJournal of Infectious Diseases
Volume200
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Nov 2009

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Gentsch, J. R., Hull, J. J., Teel, E. N., Kerin, T. K., Freeman, M. M., Esona, M. D., Griffin, D. D., Bielfelt-Krall, B. P., Banyai, K., Jiang, B., Cortese, M. M., Glass, R. I., & Parashar, U. D. (2009). G and P types of circulating rotavirus strains in the United States during 1996-2005: Nine years of prevaccine data. Journal of Infectious Diseases, 200(SUPPL. 1), S99-S105. https://doi.org/10.1086/605038