Computer Integrated Surgery has only existed for two decades, however it has already spread out world wide, with well over 100.000 operations performed. In the near future, newly developed robotic systems may conquer even the most challenging fields-such as neurosurgery-to provide better patient care and medical outcome. This paper presents the major systems and different strategies applied in robotic neurosurgery. Besides appropriate design, adequate control strategies are required to ensure maximal safety. This makes automated neurosurgery a technologically challenging area for researchers. It is also important during the design phase to consider market aspects. We anticipate that the future trends of clinical applications are outlined by the current leading research directions. The conclusions of the past years of innovation will lead forward on the path of further improvement.