Oxidative cyclization of 3-isoquinolyl ketone hydrazones afforded the novel tricyclic heteroaromatic [1,2,3]triazolo[1,5-b]isoquinolinium salts. The reactivity of the ring system towards nucleophiles proved to be regioselective. Secondary amines induced ring opening of the pyridine moiety, forming a triazolyl substituted benzaldehyde derivative; sodium borohydride afforded partially reduced derivatives of the parent compound.
- Indole synthesis
- Regiospecificity, Ring opening
- Ring closure
- Triazolium salt
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