Further syntheses with nitroxide α,β-unsaturated aldehydes and allylic bromides

Kálmán Hideg, József Csekö, H. Olga Hankovszky, Pál Sohár

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Abstract

The enhanced reactivity of nitroxide allylic bromides is used for preparation of spin-labelled analogues of biologically active compounds (morphine, Nalorphine, barbituric acid, choline and acetyl choline). Nitroxide α,β-unsaturated aldehydes are reacted with phosphoranes to give nitroxide polyenes. The nitroxides are reduced to diamagnetic N-hydroxy hydrochloride salts, which can be converted in the presence of base to N-acetoxy derivatives.

Original languageEnglish
Pages (from-to)1482-1490
Number of pages9
JournalCanadian Journal of Chemistry
Volume64
Issue number8
Publication statusPublished - Jan 1 1986

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ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Organic Chemistry

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