Further syntheses with nitroxide α,β-unsaturated aldehydes and allylic bromides

K. Hideg, József Csekö, H. Olga Hankovszky, P. Sohár

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The enhanced reactivity of nitroxide allylic bromides is used for preparation of spin-labelled analogues of biologically active compounds (morphine, Nalorphine, barbituric acid, choline and acetyl choline). Nitroxide α,β-unsaturated aldehydes are reacted with phosphoranes to give nitroxide polyenes. The nitroxides are reduced to diamagnetic N-hydroxy hydrochloride salts, which can be converted in the presence of base to N-acetoxy derivatives.

Original languageEnglish
Pages (from-to)1482-1490
Number of pages9
JournalCanadian Journal of Chemistry
Volume64
Issue number8
Publication statusPublished - 1985

Fingerprint

Choline
Aldehydes
Bromides
Phosphoranes
Nalorphine
Polyenes
Morphine
Salts
Derivatives
Acids
barbituric acid

ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Catalysis

Cite this

Further syntheses with nitroxide α,β-unsaturated aldehydes and allylic bromides. / Hideg, K.; Csekö, József; Hankovszky, H. Olga; Sohár, P.

In: Canadian Journal of Chemistry, Vol. 64, No. 8, 1985, p. 1482-1490.

Research output: Contribution to journalArticle

Hideg, K. ; Csekö, József ; Hankovszky, H. Olga ; Sohár, P. / Further syntheses with nitroxide α,β-unsaturated aldehydes and allylic bromides. In: Canadian Journal of Chemistry. 1985 ; Vol. 64, No. 8. pp. 1482-1490.
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