Further prove on oxidative stress in alloxan diabetic rat tissues

M. Sasvari, M. Sasvári, M. Kotormán, D. Q. Hai, C. Varga

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

After intravenous administration of alloxan monohydrate (AL) diabetes developed in rats. Forty-eight hours after the injection the animals were sacrificed, their blood was collected in heparin containing tubes and the tissues were dissected and frozen (-70 °C) until their homogenization for pro- and antioxidant testing. Our results can be summarised as follows: (i) In the blood hemolysate the lipid peroxidation slightly elevated and the activity of antioxidant enzymes and reduced glutathione decreased. (ii) Similar phenomena could be observed in the different examined organ homogenates. The organs tested for pro- and antioxidant system were as follows: the liver, heart, skeletal muscle, kidney and pancreas. In our present work we attempt to confirm the data in support of the oxidative predominance over antioxidants in oxidative stress of AL diabetic rats.

Original languageEnglish
Pages (from-to)183-192
Number of pages10
JournalActa Physiologica Hungarica
Volume85
Issue number3
Publication statusPublished - 1997

Fingerprint

Alloxan
Oxidative Stress
Antioxidants
Experimental Diabetes Mellitus
Intravenous Administration
Lipid Peroxidation
Glutathione
Heparin
Pancreas
Myocardium
Skeletal Muscle
Kidney
Injections
Liver
Enzymes

Keywords

  • Alloxan
  • Antioxidant system
  • Diabetes
  • Oxidative stress

ASJC Scopus subject areas

  • Physiology

Cite this

Further prove on oxidative stress in alloxan diabetic rat tissues. / Sasvari, M.; Sasvári, M.; Kotormán, M.; Hai, D. Q.; Varga, C.

In: Acta Physiologica Hungarica, Vol. 85, No. 3, 1997, p. 183-192.

Research output: Contribution to journalArticle

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