Further investigations in hplc systems containing silica and polar bonded silica packing dynamically modified by camphorsulfonic acid

A. L. Lore, Gy Szasz, Zs Budvari-Barany

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The investigation of chromatographic (HPLC) systems containing camphorsulfonic acid (CSA) has been continued. Similarly to the previous finding for silica, on polar bonded silica packings CSA forms double layer. The adsorbed amount of CSA was determined by the evaluation of break-through curves. It was found that the addition of triethylamine in a small excess to the CSA containing eluent results in the formation of a versatile chromatographic system. The adsorbed amount of CSA and TEA from such eluents was determined by the estimation of the break-through curves were gained by simultaneous refractometric and UV spectrophotometric detection. The migration of the compounds follows a normal phase mechanism evidenced by the behavior of the examined medicinal compounds.

Original languageEnglish
Pages (from-to)287-295
Number of pages9
JournalJournal of Liquid Chromatography
Volume18
Issue number2
DOIs
Publication statusPublished - Jan 1 1995

ASJC Scopus subject areas

  • Molecular Medicine

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